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New CTX-M group conferring β-Lactam resistance: A compendium of phylogenetic insights from biochemical, molecular, and structural biology

2022-02-07Journal article Open access
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dc.contributor.authorMendonça, Jacinta
dc.contributor.authorGuedes, Carla
dc.contributor.authorSilva, Carina
dc.contributor.authorSá, Sara
dc.contributor.authorOliveira, Marco
dc.contributor.authorAccioly, Gustavo
dc.contributor.authorBaylina, Pilar
dc.contributor.authorBarata, Pedro
dc.contributor.authorPereira, Cláudia
dc.contributor.authorFernandes, Ruben
dc.date.accessioned2024-04-08T14:05:38Z
dc.date.available2024-04-08T14:05:38Z
dc.date.issued2022-02-07
dc.description.abstractThe production of extended-spectrum β-lactamases (ESBLs) is the main defense mechanism found in Gram negative bacteria. Among all the ESBLs, the CTX-M enzymes appear as the most efficient in terms of dissemination in different epidemiological contexts. CTX-M enzymes exhibit a striking plasticity, with a large number of allelic variants distributed in several sublineages, which can be associated with functional heterogeneity of clinical relevance. This observational analytical study provides an update of this family, currently with more than 200 variants described, from a phylogenetic, molecular, and structural point of view through homology in amino acid sequences. Our data, combined with described literature, provide phylogenetic and structural evidence of a new group. Thus, herein, we propose six groups among CTX-M enzymes: the already stablished CTX-M-1, CTX-M-2, CTX-M-8, CTX-M-9, and CTX-M-25 clusters, as well as CTX-M-151 as the new cluster.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMendonça, J., Guedes, C., Silva, C., Sá, S., Oliveira, M., Accioly, G., Baylina, P., Barata, P., Pereira, C., & Fernandes, R. (2022). New CTX-M group conferring β-Lactam resistance: A compendium of phylogenetic insights from biochemical, molecular, and structural biology. Biology, 11(2), Artigo 2. https://doi.org/10.3390/biology11020256pt_PT
dc.identifier.doi10.3390/biology11020256pt_PT
dc.identifier.eissn2079-7737
dc.identifier.urihttp://hdl.handle.net/10400.22/25304
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationThis research received with the support of the “Programa Operacional Regional do Norte” (Norte2020), by Portugal 2020 and the “Fundo Europeu de Desenvolvimento Regional” (FEDER) (Norte-01-0145-FEDER-000012), by Fundação para Ciência e Tecnologia FCT) UID/BIM/04293/2013 and cofunded by the projects FEDER/02/SAICT/2020/072560, RESEARCH4COVID, 104_596694627, RESEARCH4COVID 112_596698921, AND RESEARCH4COVID 2nd ED 418_613508517.pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2079-7737/11/2/256pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCTX-M β-lactamasespt_PT
dc.subjectExtended-spectrum β-lactamases (ESBL)pt_PT
dc.subjectCTX-M-151 new grouppt_PT
dc.titleNew CTX-M group conferring β-Lactam resistance: A compendium of phylogenetic insights from biochemical, molecular, and structural biologypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage16pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleBiologypt_PT
oaire.citation.volume11(2)pt_PT
person.familyNameGuedes
person.familyNameSilva
person.familyNameBAYLINA MACHADO
person.givenNameCarla
person.givenNameCarina
person.givenNamePILAR
person.identifier1888845
person.identifier.ciencia-id2B11-8C00-A60D
person.identifier.ciencia-id671E-DB22-A2AB
person.identifier.ciencia-id1419-F23D-4920
person.identifier.orcid0000-0002-3277-7821
person.identifier.orcid0000-0003-1711-0858
person.identifier.orcid0000-0002-3740-862X
person.identifier.ridD-3704-2017
person.identifier.ridB-5134-2010
person.identifier.scopus-author-id57447314300
person.identifier.scopus-author-id56534079700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa1736eb9-65d6-4da5-873e-1b36f7b6e0fb
relation.isAuthorOfPublicationa934918a-e52b-43e4-b812-748b5adc6de7
relation.isAuthorOfPublicationb1482a24-d9d8-419d-af68-6df1a75afb3f
relation.isAuthorOfPublication.latestForDiscoverya934918a-e52b-43e4-b812-748b5adc6de7

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