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Targeting the Tumor Microenvironment: An Unexplored Strategy for Mutant KRAS Tumors

2019Journal article Open access
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dc.contributor.authorDias Carvalho, PatrĆ­cia
dc.contributor.authorMachado, Ana LuĆ­sa
dc.contributor.authorMartins, FlƔvia
dc.contributor.authorSeruca, Raquel
dc.contributor.authorVELHO, SERGIA
dc.date.accessioned2020-02-03T15:09:12Z
dc.date.available2020-02-03T15:09:12Z
dc.date.issued2019
dc.description.abstractCurrent evidence strongly suggests that cancer cells depend on the microenvironment in order to thrive. In fact, signals from the surrounding tumor microenvironment are crucial for cancer cellsĀ“ aggressiveness, altering their expression profile and favoring their metastatic potential. As such, targeting the tumor microenvironment to impair cancer progression became an attractive therapeutic option. Interestingly, it has been shown that oncogenic KRAS signaling promotes a pro-tumorigenic microenvironment, and the associated crosstalk alters the expression profile of cancer cells. These findings award KRAS a key role in controlling the interactions between cancer cells and the microenvironment, granting cancer a poor prognosis. Given the lack of effective approaches to target KRAS itself or its downstream effectors in the clinic, exploring such interactions may open new perspectives on possible therapeutic strategies to hinder mutant KRAS tumors. This review highlights those communications and their implications for the development of effective therapies or to provide insights regarding response to existing regimens.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/cancers11122010pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/15424
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationNORTE-01-0145-FEDER-000029pt_PT
dc.relationNORTE-01-0145-FEDER-000012pt_PT
dc.relationExploring the impact of mutant KRAS on epithelial-fibroblasts interactions during colorectal cancer initiation and progression
dc.relation.publisherversionhttps://www.mdpi.com/2072-6694/11/12/2010pt_PT
dc.subjectTumor microenvironmentpt_PT
dc.subjectCancer therapypt_PT
dc.subjectImmunotherapypt_PT
dc.subjectLung cancerpt_PT
dc.subjectKRASpt_PT
dc.subjectColorectal cancerpt_PT
dc.subjectPancreatic cancerpt_PT
dc.titleTargeting the Tumor Microenvironment: An Unexplored Strategy for Mutant KRAS Tumorspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleExploring the impact of mutant KRAS on epithelial-fibroblasts interactions during colorectal cancer initiation and progression
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FMED-ONC%2F31354%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F131156%2F2017/PT
oaire.citation.issue12pt_PT
oaire.citation.startPage2010pt_PT
oaire.citation.titleCancerspt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream9471 - RIDTI
person.familyNameSeruca
person.familyNameVELHO
person.givenNameRaquel
person.givenNameSERGIA
person.identifierqmAvPh0AAAAJ&hl
person.identifier.ciencia-idAF16-3243-F4EF
person.identifier.ciencia-idB316-B47C-2855
person.identifier.orcid0000-0002-8851-4166
person.identifier.orcid0000-0002-7104-8234
person.identifier.scopus-author-id7006207833
person.identifier.scopus-author-id8738558400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundaĆ§Ć£o para a CiĆŖncia e a Tecnologia
project.funder.nameFundaĆ§Ć£o para a CiĆŖncia e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication737b6e3c-5bef-4fc2-bb65-20d5c9549148
relation.isAuthorOfPublication53d5cdfd-bd50-4d3d-94bf-246969285ad1
relation.isAuthorOfPublication.latestForDiscovery737b6e3c-5bef-4fc2-bb65-20d5c9549148
relation.isProjectOfPublication5a292769-5590-4e55-8c9d-48bd7faa07d8
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