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Unveiling Urinary Mutagenicity by the Ames Test for Occupational Risk Assessment: A Systematic Review

2022-10-11Journal article Open access
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dc.contributor.authorBarros, Bela
dc.contributor.authorOliveira, Marta
dc.contributor.authorMorais, Simone
dc.date.accessioned2023-01-27T14:00:18Z
dc.date.available2023-01-27T14:00:18Z
dc.date.issued2022-10-11
dc.description.abstractOccupational exposure may involve a variety of toxic compounds. A mutagenicity analysis using the Ames test can provide valuable information regarding the toxicity of absorbed xenobiotics. Through a search of relevant databases, this systematic review gathers and critically discusses the published papers (excluding other types of publications) from 2001–2021 that have assessed urinary mutagenicity (Ames test with Salmonella typhimurium) in an occupational exposure context. Due to the heterogeneity of the study methods, a meta-analysis could not be conducted. The characterized occupations were firefighters, traffic policemen, bus drivers, mail carriers, coke oven and charcoal workers, chemical laboratory staff, farmers, pharmacy workers, and professionals from several other industrial sectors. The genetically modified bacterial strains (histidine dependent) TA98, TA100, YG1041, YG1021, YG1024 and YG1042 have been used for the health risk assessment of individual (e.g., polycyclic aromatic hydrocarbons) and mixtures of compounds (e.g., diesel engine exhaust, fire smoke, industrial fumes/dyes) in different contexts. Although comparison of the data between studies is challenging, urinary mutagenicity can be very informative of possible associations between work-related exposure and the respective mutagenic potential. Careful interpretation of results and their direct use for occupational health risk assessment are crucial and yet complex; the use of several strains is highly recommended since individual and/or synergistic effects of complex exposure to xenobiotics can be overlooked. Future studies should improve the methods used to reach a standardized protocol for specific occupational environments to strengthen the applicability of the urinary mutagenicity assay and reduce inter- and intra-individual variability and exposure source confounderspt_PT
dc.description.sponsorshipThis work received financial support from the projects PCIF/SSO/0017/2018 and PCIF/SSO/0090/2019 of the Fundação para a Ciência e a Tecnologia (FCT), Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through national funds. This work received support from UIDB/50006/2020, UIDP/50006/2020 and LA/P/0008/2020. M. Oliveira and B. Barros were supported by the scientific contract CEEC Individual 2017 Program Contract CEECIND/03666/2017 and the Ph.D. grant 2020.07394.BD, respectively. These were supported by the FCT and the European Union through the Fundo Social Europeu (FSE) and Ministério da Ciência, Tecnologia e Ensino Superior, respectively.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/ijerph192013074pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/21949
dc.language.isoengpt_PT
dc.publisherMDPIpt_PT
dc.relationLA/P/0008/2020pt_PT
dc.relationFirefighting occupational exposure and early effects on the health of operational forces
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationNot Available
dc.relationForest Fire emissions: Exposure data and potential health risks for firefighters and the general population.
dc.relation.publisherversionhttps://www.mdpi.com/1660-4601/19/20/13074pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectUrinary biomarkerpt_PT
dc.subjectToxic exposurept_PT
dc.subjectOccupational healthpt_PT
dc.subjectMutagenicitypt_PT
dc.titleUnveiling Urinary Mutagenicity by the Ames Test for Occupational Risk Assessment: A Systematic Reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleFirefighting occupational exposure and early effects on the health of operational forces
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleNot Available
oaire.awardTitleForest Fire emissions: Exposure data and potential health risks for firefighters and the general population.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PCIF%2FSSO%2F0017%2F2018/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PCIF%2FSSO%2F0090%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F03666%2F2017%2FCP1427%2FCT0007/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2020.07394.BD/PT
oaire.citation.issue20pt_PT
oaire.citation.startPage13074pt_PT
oaire.citation.titleInternational Journal of Environmental Research and Public Healthpt_PT
oaire.citation.volume19pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 2017
person.familyNameCoelho Barros
person.familyNameMarques de Oliveira
person.familyNameMorais
person.givenNameAna Bela
person.givenNameMarta Madalena
person.givenNameSimone
person.identifierE-1761-2011
person.identifier1598822
person.identifier.ciencia-id451F-F5E7-ABAA
person.identifier.ciencia-id0A1C-A89D-641A
person.identifier.ciencia-idB111-BBFB-F200
person.identifier.orcid0000-0003-1779-7688
person.identifier.orcid0000-0003-4150-0151
person.identifier.orcid0000-0001-6433-5801
person.identifier.scopus-author-id57202841330
person.identifier.scopus-author-id7007053747
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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