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Advisor(s)
Abstract(s)
Introdução
Os potenciais evocados auditivos de média latência
(PEAML) reflectem actividade neuronal mesencefáfica, mais
precisamente da região tálamo-cortical, dos colículos inferiores
e da formação reticular. A epilepsia é caracterizada por
variadas manifestações anormais do comportamento cerebral,
sendo descrita como uma perturbação da função cerebral,
tendo origem numa descarga anómala de um conjunto
ou da totalidade dos neurónios do córtice cerebral. Está documentado,
que as descargas eléctricas provocadas pelas crises
de epilepsia podem levar a perdas neuronais, pelo que poderão
existir alterações nos PEAML.
Objectivos
A escassa existência de literatura sobre o tema e a não
investigação na população portuguesa, originou a execução
deste estudo, que teve como objectivo investigar e documentar
a existência de alterações ou achados nos componentes
neuronais de média latência (PEAML), numa amostra de portugueses
com epilepsia.
Metodologia
Foram realizados PEAML a um grupo de controlo (GC)
composto por 16 participantes e a um grupo clínico (GCL) de
8 participantes com epilepsia, sendo analisados os componentes
Na, Pa e Na-Pa quanto à sua morfologia, latência e
amplitude.
Resultados
A morfologia das ondas e a presença de epilepsia não estão
associados, no entanto, contrariamente ao GC que evidenciou
latências e amplitudes de Na, Pa e Na-Pa dentro dos padrões
de normalidade, a alteração ou ausência de respostas por
parte do GCL é significativa na totalidade das medidas investigadas.
Conclusão
Em epilepsias generalizadas e focais do lobo temporal os
PEAML evidenciam alterações, tal achado poderá ser eventualmente
justificado pela propagação ascendente e descendente
da informação auditiva se encontrar comprometida,
devido a sequelas deixadas pelas crises epilépticas nas vias
auditivas mesencefálicas. As alterações verificadas foram uma
morfologia anómala das ondas ou ausência das mesmas.
Introduction The auditory middle latency response (AMLR) reflects neural mid brain activity, more precisely of the region thalamus–cortical, of the inferior colliculus and of the reticular formation. Epilepsy is characterized by different anomalous manifestations of the behaviour of the mind, being described as a disturbance of the brain function, originated in an anomalous discharge of a set or totality of the neuron of the brain cortex. It is proved that the electrical discharges caused by epileptic seizures can lead to neuron losses and a hypothesis was considered of existing changes in AMLR. Objectives The scarce existing literature about this theme and no investigation in the Portuguese population motivated the present study, who´s aim is to investigate and document the existing changes or discoveries in the components of AMLR in a sample of Portuguese patients with epilepsy. Method AMLR were carried out with a control group (CG) formed by 16 participants and with a clinical group (CLG) of 8 participants with epilepsy being analysed the Na, Pa and Na-Pa components concerning its morphology, latency and amplitude. Results The observed results show that the morphology of waves and the presence of epilepsy are not associated, while the changes or absence of responses from the CLG is significant in all the studied variables, in opposition to the CG that showed latencies of Na, Pa and Na-Pa within the normal standards. Conclusions We can conclude that the presence of generalized or temporal lobe epilepsies the AMLR show changes. This discovery may be justified by the ascendant and descendant diffusion of auditory information compromised due to sequels of epileptic seizures in the auditory midbrain pathways. The verified changes were an anomalous morphology of waves or their absence.
Introduction The auditory middle latency response (AMLR) reflects neural mid brain activity, more precisely of the region thalamus–cortical, of the inferior colliculus and of the reticular formation. Epilepsy is characterized by different anomalous manifestations of the behaviour of the mind, being described as a disturbance of the brain function, originated in an anomalous discharge of a set or totality of the neuron of the brain cortex. It is proved that the electrical discharges caused by epileptic seizures can lead to neuron losses and a hypothesis was considered of existing changes in AMLR. Objectives The scarce existing literature about this theme and no investigation in the Portuguese population motivated the present study, who´s aim is to investigate and document the existing changes or discoveries in the components of AMLR in a sample of Portuguese patients with epilepsy. Method AMLR were carried out with a control group (CG) formed by 16 participants and with a clinical group (CLG) of 8 participants with epilepsy being analysed the Na, Pa and Na-Pa components concerning its morphology, latency and amplitude. Results The observed results show that the morphology of waves and the presence of epilepsy are not associated, while the changes or absence of responses from the CLG is significant in all the studied variables, in opposition to the CG that showed latencies of Na, Pa and Na-Pa within the normal standards. Conclusions We can conclude that the presence of generalized or temporal lobe epilepsies the AMLR show changes. This discovery may be justified by the ascendant and descendant diffusion of auditory information compromised due to sequels of epileptic seizures in the auditory midbrain pathways. The verified changes were an anomalous morphology of waves or their absence.
Description
Keywords
Potenciais evocados auditivos de média latência Epilepsia Mesencéfalo Auditory middle latency response (AMLR) Epilepsy Mid brain
Citation
Tomé, D., Jesus, E., & Esteves, M. (2011). Potenciais evocados auditivos de média latência em adultos com epilepsia. Sinapse, Vol. 11(No 1), 25–31.
Publisher
Sociedade Portuguesa de Neurologia