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Paroxysmal nocturnal hemoglobinuria: a case report in a pandemic environment

2023-09-08Journal article Open access
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dc.contributor.authorPeixoto, Vanda
dc.contributor.authorCarneiro, Ana
dc.contributor.authorTrigo, Fernanda
dc.contributor.authorVieira, Mónica
dc.contributor.authorPrudêncio, Cristina
dc.date.accessioned2023-09-11T15:31:11Z
dc.date.available2023-09-11T15:31:11Z
dc.date.issued2023-09-08
dc.description.abstractParoxysmal nocturnal hemoglobinuria (PNH) is a clonal, rare, complement-mediated hemolytic anemia. PNH can be associated with marrow failure and thrombophilia. We present a clinical report of splenic vein thrombosis in a patient with classic PNH. A 41-year-old male with classic PNH, naïve to complement inhibitor therapy, developed splenic vein thrombosis as a major adverse effect after vaccination protocol to prevent meningococcal disease. We also report anticoagulant and eculizumab treatment outcomes. In PNH patients, vaccination should be monitored to prevent major outcome events, like vaccine-induced thrombosis. Eculizumab proves effective for treating intravascular hemolysis and preventing more thrombotic events. The potential protective role of eculizumab on controlling complement activity and consequent inflammation may help the patient to not experience breakthrough hemolysis when infected with SARS-CoV-2. Extravascular hemolysis remains present, but new molecules are being studied to inhibit proximal complement and there is a good health prospective for PNH patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPeixoto, V., Carneiro, A., Trigo, F., Vieira, M., & Prudêncio, C. (2023). Paroxysmal Nocturnal Hemoglobinuria: A Case Report in a Pandemic Environment. Reports, 6(3), Artigo 3. https://doi.org/10.3390/reports6030042pt_PT
dc.identifier.eissn2571-841X
dc.identifier.urihttp://hdl.handle.net/10400.22/23502
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2571-841X/6/3/42pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectParoxysmal nocturnal hemoglobinuriapt_PT
dc.subjectVaccinespt_PT
dc.subjectThrombosispt_PT
dc.subjectEculizumabpt_PT
dc.subjectCOVID-19pt_PT
dc.titleParoxysmal nocturnal hemoglobinuria: a case report in a pandemic environmentpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage10pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleReportspt_PT
oaire.citation.volume6(3)pt_PT
person.familyNamePeixoto
person.familyNameAlmeida Vieira
person.familyNamePrudêncio
person.givenNameVanda
person.givenNameMónica Andreia
person.givenNameCristina
person.identifier1200571
person.identifier.ciencia-idA01E-9178-9B48
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.orcid0000-0003-4883-3186
person.identifier.orcid0000-0002-8687-4811
person.identifier.orcid0000-0002-9920-936X
person.identifier.scopus-author-id6508057930
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationaf5cb379-3640-49bc-9d0a-43dd212821a1
relation.isAuthorOfPublication861e9c68-4ecc-4be1-a794-852343368e9a
relation.isAuthorOfPublication881a8ad5-ab13-4e49-89f4-08ca61cc81e3
relation.isAuthorOfPublication.latestForDiscovery881a8ad5-ab13-4e49-89f4-08ca61cc81e3

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