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Static and hydrodynamic monitoring of citalopram based on its electro-oxidation behavior at a glassy-carbon surface

dc.contributor.authorNouws, Henri P. A.
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorBarros, Aquiles A.
dc.contributor.authorMaesen, Els
dc.contributor.authorMoreira, Silvana
dc.contributor.authorNeves, Marta M. P. S.
dc.date.accessioned2013-11-25T13:01:49Z
dc.date.available2013-11-25T13:01:49Z
dc.date.issued2008
dc.description.abstractThe electrooxidative behavior of citalopram (CTL) in aqueous media was studied by cyclic voltammetry (CV) and square-wave voltammetry (SWV) at a glassy-carbon electrode. The electrochemical behaviour of CTL involves two electrons and two protons in the irreversible and diffusion controlled oxidation of the tertiary amine group. The maximum analytical signal was obtained in a phosphate buffer (pH ¼ 8.2). For analytical purposes, an SWV method and a flow-injection analysis (FIA) system with amperometric detection were developed. The optimised SWV method showed a linear range between 1.10 10 5–1.20 10 4 molL 1, with a limit of detection (LOD) of 9.5 10 6 molL 1. Using the FIA method, a linear range between 2.00 10 6–9.00 10 5 molL 1 and an LODof 1.9 10 6 molL 1 were obtained. The validation of both methods revealed good performance characteristics confirming applicability for the quantification of CTL in several pharmaceutical products.por
dc.identifier.doi10.1080/00032710802238069pt_PT
dc.identifier.issn0003-2719
dc.identifier.issn1532-236X
dc.identifier.urihttp://hdl.handle.net/10400.22/2942
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherTaylor & Francispor
dc.relation.ispartofseriesAnalytical Letters; Vol. 41, Issue 12
dc.relation.publisherversionhttp://www.tandfonline.com/doi/abs/10.1080/00032710802238069#.UooGin9qyZQpor
dc.subjectAmperometric detectionpor
dc.subjectCitaloprampor
dc.subjectFlow-injection analysispor
dc.subjectPharmaceutical analysispor
dc.subjectSquare-wave voltammetrypor
dc.titleStatic and hydrodynamic monitoring of citalopram based on its electro-oxidation behavior at a glassy-carbon surfacepor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2185por
oaire.citation.issueIssue 12
oaire.citation.startPage2171por
oaire.citation.titleAnalytical Letters
oaire.citation.volumeVol. 41
person.familyNameDelerue-Matos
person.givenNameCristina
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id6603741848
rcaap.rightsclosedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isAuthorOfPublication.latestForDiscovery09f6a7bd-2f15-42b0-adc5-04bd22210519

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