Publicação
ß-Lactams: chemical structure, mode of action and mechanisms of resistance
| dc.contributor.author | Fernandes, Rúben | |
| dc.contributor.author | Amador, Paula | |
| dc.contributor.author | Prudêncio, Cristina | |
| dc.date.accessioned | 2015-12-01T15:35:53Z | |
| dc.date.available | 2020-01-01T01:30:13Z | |
| dc.date.issued | 2013 | |
| dc.date.updated | 2013-07-25T20:43:23Z | |
| dc.description.abstract | This synopsis summarizes the key chemical and bacteriological characteristics of β-lactams, penicillins, cephalosporins, carbanpenems, monobactams and others. Particular notice is given to first-generation to fifth-generation cephalosporins. This review also summarizes the main resistance mechanism to antibiotics, focusing particular attention to those conferring resistance to broad-spectrum cephalosporins by means of production of emerging cephalosporinases (extended-spectrum β-lactamases and AmpC β-lactamases), target alteration (penicillin-binding proteins from methicillin-resistant Staphylococcus aureus) and membrane transporters that pump β-lactams out of the bacterial cell. | pt_PT |
| dc.identifier.citation | Fernandes, Rúben; Amador, Paula; Prudêncio, Cristina. ß-Lactams: chemical structure, mode of action and mechanisms of resistance, Reviews in Medical Microbiology, 24, 1, 7-17, 2013. | pt_PT |
| dc.identifier.doi | 10.1097/MRM.0b013e3283587727 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.22/7041 | |
| dc.language.iso | eng | pt_PT |
| dc.publisher | Wolters Kluwer Health | Lippincott Williams & Wilkins | pt_PT |
| dc.relation.publisherversion | http://journals.lww.com/revmedmicrobiol/Abstract/2013/01000/__Lactams___chemical_structure,_mode_of_action_and.2.aspx | pt_PT |
| dc.title | ß-Lactams: chemical structure, mode of action and mechanisms of resistance | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 17 | pt_PT |
| oaire.citation.startPage | 7 | pt_PT |
| oaire.citation.title | Reviews in Medical Microbiology | pt_PT |
| oaire.citation.volume | 24 | pt_PT |
| person.familyName | Fernandes | |
| person.familyName | Prudêncio | |
| person.givenName | Rúben | |
| person.givenName | Cristina | |
| person.identifier | 635792 | |
| person.identifier | 1200571 | |
| person.identifier.ciencia-id | 0D1F-4090-E82A | |
| person.identifier.ciencia-id | C81E-F4EE-FADE | |
| person.identifier.orcid | 0000-0001-8933-3984 | |
| person.identifier.orcid | 0000-0002-9920-936X | |
| person.identifier.scopus-author-id | 57640135700 | |
| person.identifier.scopus-author-id | 6508057930 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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