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Postnatal exposure to cocaine in rats housed in an enriched environment: effects on social interactions

2007-04-01Journal article Open access
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dc.contributor.authorMagalhães, Ana
dc.contributor.authorSummavielle, Teresa
dc.contributor.authorTavares, Maria Amélia
dc.contributor.authorSousa, Liliana de
dc.date.accessioned2021-09-28T15:07:47Z
dc.date.available2021-09-28T15:07:47Z
dc.date.issued2007-04-01
dc.description.abstractThis study was undertaken to evaluate the effects of environmental enrichment (EE) in rats exposed to cocaine during the first month of postnatal life by examining several categories of social behaviour (play fighting, social investigation, comfort behaviours and invitation to play). Wistar rats were divided in four groups: pups exposed to cocaine hydrochloride (15 mg/kg body weight/day), sc, in two daily doses, from postnatal day (PND) 1 to 28 and reared in EE; exposed to cocaine as previously described and reared in standard environment (SE); saline-exposed and reared in EE; pups saline-exposed and reared in SE. On PND 21, 24 and 28, social interactions were examined for 10 min. Results show that cocaine animals reared in SE decreased the frequency of play solicitation. Control animals reared in EE exhibited decreased play fighting and social investigation behaviours compared to SE-reared rats. Animals postnatally exposed to cocaine when reared in EE displayed more comfort and invitation to play behaviours and decreased social investigation compared with SE-reared animals. The results suggest that in rats postnatally exposed to cocaine, EE rearing elicited differences in both processing of environmental stimuli and a response to social challenges. Human & Experimental Toxicology (2007) 26, 303-309pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMagalhães, A., Summavielle, T., Tavares, M. A., & de Sousa, L. (2007). Postnatal exposure to cocaine in rats housed in an enriched environment: effects on social interactions. Human & Experimental Toxicology, 26(4), 303-309. https://doi.org/10.1177/0960327106070458pt_PT
dc.identifier.doi10.1177/0960327106070458pt_PT
dc.identifier.issn1477-0903
dc.identifier.urihttp://hdl.handle.net/10400.22/18609
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSagept_PT
dc.relation.publisherversionhttps://journals.sagepub.com/doi/10.1177/0960327106070458?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCocainept_PT
dc.subjectDevelopmentpt_PT
dc.subjectEnriched environmentpt_PT
dc.subjectSocial interactionspt_PT
dc.titlePostnatal exposure to cocaine in rats housed in an enriched environment: effects on social interactionspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceHaikko, FINLANDpt_PT
oaire.citation.endPage309pt_PT
oaire.citation.startPage303pt_PT
oaire.citation.title10th Meeting of the International-Neurotoxicology-Associationpt_PT
oaire.citation.volume26pt_PT
person.familyNameSummavielle
person.givenNameTeresa
person.identifier677706
person.identifier.ciencia-idC41E-0816-5C85
person.identifier.orcid0000-0003-2548-6281
person.identifier.ridC-9776-2012
person.identifier.scopus-author-id6603092949
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication207ee2de-85a0-4144-9e7e-b376c600e065
relation.isAuthorOfPublication.latestForDiscovery207ee2de-85a0-4144-9e7e-b376c600e065

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