Publication
A multibiomarker approach highlights effects induced by the human pharmaceutical gemfibrozil to gilthead seabream Sparus aurata
| dc.contributor.author | Barreto, A. | |
| dc.contributor.author | Luis, L.G. | |
| dc.contributor.author | Paíga, Paula | |
| dc.contributor.author | Santos, L.H.M.L.M. | |
| dc.contributor.author | Delerue-Matos, Cristina | |
| dc.contributor.author | Soares, A.M.V.M. | |
| dc.contributor.author | Hylland, K. | |
| dc.contributor.author | Loureiro, S. | |
| dc.contributor.author | Oliveira, M. | |
| dc.date.accessioned | 2019-10-29T16:42:06Z | |
| dc.date.available | 2019-10-29T16:42:06Z | |
| dc.date.issued | 2018-05 | |
| dc.description.abstract | Lipid regulators are among the most prescribed human pharmaceuticals worldwide. Gemfibrozil, which belongs to this class of pharmaceuticals, is one of the most frequently encountered in the aquatic environment. However, there is limited information concerning the mechanisms involved in gemfibrozil effects to aquatic organisms, particularly to marine organisms. Based on this knowledge gap, the current study aimed to assess biochemical and behavioral effects following a sublethal exposure to gemfibrozil (1.5, 15, 150, 1500 and 15,000 μg L-1) in the estuarine/marine fish Sparus aurata. After the exposure to 1.5 μg L-1 of gemfibrozil, fish had reduced ability to swim against a water flow and increased lipid peroxidation in the liver. At concentrations between 15-15,000 μg L-1, the activities of some enzymes involved in antioxidant defense were induced, appearing to be sufficient to prevent oxidative damage. Depending on the organ, different responses to gemfibrozil were displayed, with enzymes like catalase being more stimulated in gills, whereas glutathione peroxidase was more activated in liver. Although there were no obvious concentration-response relationships, the integrated biomarker response version 2 (IBRv2) analysis revealed that the highest concentrations of gemfibrozil (between 150-15,000 μg L-1) caused more alterations. All the tested concentrations of gemfibrozil induced effects in S. aurata, in terms of behavior and/or oxidative stress responses. Oxidative damage was found at a concentration that is considered environmentally relevant, suggesting a potential of this pharmaceutical to impact fish populations. | pt_PT |
| dc.description.sponsorship | This research was supported through the COMPETE – Operational Competitiveness Program and National Funds through FCT – Foundation for Science and Technology, under the project “NANOAu – Effects of Gold Nanoparticles to Aquatic Organisms” (FCT PTDC/MAR-EST/3399/2012) (FCOMP-01-0124-FEDER-029435), through FCT/MCTES through national funds (PIDDAC), the cofounding by FEDER, within the PT2020 Partnership Agreement and Compete 2020 to CESAM (UID/AMB/50017 – POCI-01-0145-FEDER-007638) and UID/QUI/50006/2013. A. Barreto has a doctoral fellowship from FCT (SFRH/BD/97624/2013); L. G. Luis had a fellowship from FCT (BI/UI88/6881/2014). MO has financial support of the program Investigator FCT, co-funded by the Human Potential Operational Programme and European Social Fund (IF/00335(2015). | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1016/j.aquatox.2018.05.012 | |
| dc.identifier.issn | 0166-445X | |
| dc.identifier.uri | http://hdl.handle.net/10400.22/14766 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0166445X18302297?via%3Dihub | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt_PT |
| dc.subject | Fibrates | pt_PT |
| dc.subject | Seabream | pt_PT |
| dc.subject | Behavior | pt_PT |
| dc.subject | Biomarkers | pt_PT |
| dc.subject | Oxidative damage | pt_PT |
| dc.title | A multibiomarker approach highlights effects induced by the human pharmaceutical gemfibrozil to gilthead seabream Sparus aurata | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FAMB%2F50017%2F2013/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT | |
| oaire.citation.endPage | 274 | pt_PT |
| oaire.citation.startPage | 266 | pt_PT |
| oaire.citation.title | Aquatic Toxicology | pt_PT |
| oaire.citation.volume | 200 | pt_PT |
| oaire.fundingStream | 5876 | |
| oaire.fundingStream | 5876 | |
| person.familyName | Paíga | |
| person.familyName | Delerue-Matos | |
| person.givenName | Paula | |
| person.givenName | Cristina | |
| person.identifier | 1668889 | |
| person.identifier.ciencia-id | 331A-5D6A-D3C8 | |
| person.identifier.ciencia-id | 9A1A-43FB-5C27 | |
| person.identifier.orcid | 0000-0002-9593-1355 | |
| person.identifier.orcid | 0000-0002-3924-776X | |
| person.identifier.rid | Q-4930-2018 | |
| person.identifier.rid | D-4990-2013 | |
| person.identifier.scopus-author-id | 6506638953 | |
| person.identifier.scopus-author-id | 6603741848 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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