Repository logo
 
Publication

Differential effects of antiepileptic drugs on human bone cells

2019Journal article Open access
Simple item page
dc.contributor.authorRocha, Sara
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorFernandes, Maria Helena
dc.contributor.authorCosta-Rodrigues, Joao
dc.date.accessioned2019-07-01T12:28:23Z
dc.date.available2020-05-02T00:30:30Z
dc.date.issued2019
dc.description.abstractAntiepileptic drugs (AED) have been associated to in vivo deleterious consequences in bone tissue. The present work aimed to characterize the cellular and molecular effects of five different AED on human osteoclastogenesis and osteblastogenesis. It was observed that the different drugs had the ability to differentially modulate both processes, in a way dependent on the identity and dose of the AED. Shortly, valproic acid stimulated either osteoclastogenesis and osteoblastogenesis, whereas carbamazepine, gabapentin, and lamotrigine revealed an opposite behavior; topiramate elicited a decrease of osteoclast development and an increase in osteoblast differentiation. This is the first report describing the direct effects of different AED on human primary bone cells, which is a very important issue, because these drugs are usually consumed in long-term therapeutics, with acknowledged in vivo effects in bone tissue.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRocha, S., Ferraz, R., Prudêncio, C., Fernandes, M. H., & Costa-Rodrigues, J. (2019). Differential effects of antiepileptic drugs on human bone cells. Journal of Cellular Physiology, 234(11), 19691–19701. https://doi.org/10.1002/jcp.28569
dc.identifier.doi10.1002/jcp.28569pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/14181
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationPOCI/01/0145/FEDER/007265pt_PT
dc.relationNorte‐01–0145‐FEDER‐000024pt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/epdf/10.1002/jcp.28569pt_PT
dc.subjectAntiepileptic drugspt_PT
dc.subjectOsteoblastogenesispt_PT
dc.subjectOsteoclastogenesispt_PT
dc.titleDifferential effects of antiepileptic drugs on human bone cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.citation.titleJournal of Cellular Physiologypt_PT
oaire.fundingStream5876
person.familyNameFerraz
person.familyNamePrudêncio
person.familyNameCosta-Rodrigues
person.givenNameRicardo
person.givenNameCristina
person.givenNameJoao
person.identifier1200571
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.ciencia-id7412-B006-2120
person.identifier.orcid0000-0002-1761-117X
person.identifier.orcid0000-0002-9920-936X
person.identifier.orcid0000-0003-1375-8067
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
person.identifier.scopus-author-id6508057930
person.identifier.scopus-author-id8558383400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication881a8ad5-ab13-4e49-89f4-08ca61cc81e3
relation.isAuthorOfPublicationce85cc8f-09f3-4c26-aeaf-6128971acf68
relation.isAuthorOfPublication.latestForDiscovery881a8ad5-ab13-4e49-89f4-08ca61cc81e3
relation.isProjectOfPublication5c06a623-3499-408c-aef9-0a1f68cb1d02
relation.isProjectOfPublication.latestForDiscovery5c06a623-3499-408c-aef9-0a1f68cb1d02

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ART_Ricardo_Ferraz_2019.pdf
Size:
1000.61 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESS - CQB - Artigos
ESS - CF - Artigos