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Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumours

2013Journal article Open access
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dc.contributor.authorFerreira, José Alexandre
dc.contributor.authorVideira, Paula
dc.contributor.authorLima, Luís
dc.contributor.authorPereira, Sofia
dc.contributor.authorSilva, Mariana
dc.contributor.authorCarrascal, Milene
dc.contributor.authorSeverino, Paulo
dc.contributor.authorFernandes, Elisabete
dc.contributor.authorAlmeida, Andreia
dc.contributor.authorCosta, Céu
dc.contributor.authorVitorino, Rui
dc.contributor.authorAmaro, Teresina
dc.contributor.authorOliveira, Maria José
dc.contributor.authorReis, Celso
dc.contributor.authorDall'Olio, Fabio
dc.contributor.authorAmado, Francisco
dc.contributor.authorSantos, Lúcio
dc.date.accessioned2014-01-01T14:02:42Z
dc.date.available2014-01-01T14:02:42Z
dc.date.issued2013
dc.description.abstractLittle is known on the expression of the tumour-associated carbohydrate antigen sialyl-Tn (STn), in bladder cancer. We report here that 75% of the high-grade bladder tumours, presenting elevated proliferation rates and high risk of recurrence/progression expressed STn. However, it was mainly found in non-proliferative areas of the tumour, namely in cells invading the basal and muscle layers. STn was also found in tumour-adjacent mucosa, which suggests its dependence on a field effect of the tumour. Furthermore, it was not expressed by the normal urothelium, demonstrating the cancer-specific nature of this antigen. STn expression correlated with that of sialyltransferase ST6GalNAc.I, its major biosynthetic enzyme. The stable expression of ST6GalNAc.I in the bladder cancer cell line MCR induced STn expression and a concomitant increase of cell motility and invasive capability. Altogether, these results indicate for the first time a link between STn expression and malignancy in bladder cancer. Hence, therapies targeting STn may constitute new treatment approaches for these tumours.por
dc.identifier.doi10.1016/j.molonc.2013.03.001pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/3173
dc.language.isoeng
dc.peerreviewedyespor
dc.publisherElsevier
dc.relation.ispartofseriesMolecular Oncology; Vol. 7, Nº 3
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1574789113000458
dc.subjectSialyl:Tnpor
dc.subjectBladder cancerpor
dc.subjectGlycosylationpor
dc.subjectST6GalNAc.Ipor
dc.subjectTumour-associated glycanspor
dc.subjectproliferative bladder cancerpor
dc.titleOverexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumourspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlacePortugalpor
oaire.citation.endPage731por
oaire.citation.issueNº 3
oaire.citation.startPage719por
oaire.citation.titleMolecular Oncologypor
oaire.citation.volumeVol. 7por
person.familyNameOliveira Lima
person.givenNameLuís Carlos
person.identifier.ciencia-id9F16-0E29-D9FC
person.identifier.orcid0000-0001-8152-9237
person.identifier.scopus-author-id23501978900
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationc6b00c1f-f4c9-4f4f-b291-17cf30b1e1f8
relation.isAuthorOfPublication.latestForDiscoveryc6b00c1f-f4c9-4f4f-b291-17cf30b1e1f8

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