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Early-life stress affects drug abuse susceptibility in adolescent rat model independently of depression vulnerability

2020Journal article Open access
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dc.contributor.authorAlves, Renata L.
dc.contributor.authorOliveira, Pedro
dc.contributor.authorLopes, Igor M.
dc.contributor.authorPortugal, Camila C.
dc.contributor.authorAlves, Cecília J.
dc.contributor.authorBarbosa, Fernando
dc.contributor.authorSummavielle, Teresa
dc.contributor.authorMagalhães, Ana
dc.date.accessioned2020-09-14T10:32:45Z
dc.date.available2020-09-14T10:32:45Z
dc.date.issued2020
dc.description.abstractThe development of substance abuse problems occurs due to a diverse combination of risk factors. Among these risks, studies have reported depression and early-life stress as of importance. These two factors often occur simultaneously, however, there is a lack of understanding of how their combined effect may impact vulnerability to drug abuse in adolescence. The present study used rats with different vulnerability to depression (Wistar and Wistar-Kyoto) to investigate the impact of maternal separation (MS) on emotional state and drug addiction vulnerability during the adolescence period. Mothers and their litters were subjected to MS (180 min/day) from postnatal day 2 to 14. The offspring emotional state was assessed by observing their exploratory behavior. Drug abuse vulnerability was assessed through conditioning to cocaine. MS impacted the emotional state in both strains. Wistar responded with increased exploration, while Wistar-Kyoto increased anxiety-like behaviours. Despite the different coping strategies displayed by the two strains when challenged with the behavioural tests, drug conditioning was equally impacted by MS in both strains. Early-life stress appears to affect drug abuse vulnerability in adolescence independently of a depression background, suggesting emotional state as the main driving risk factor.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlves, R. L., Oliveira, P., Lopes, I. M., Portugal, C. C., Alves, C. J., Barbosa, F., Summavielle, T., & Magalhães, A. (2020). Early-life stress affects drug abuse susceptibility in adolescent rat model independently of depression vulnerability. Scientific Reports, 10(1), 13326. https://doi.org/10.1038/s41598-020-70242-4
dc.identifier.doi10.1038/s41598-020-70242-4pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/16249
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationPOCI-01-0145-FEDER-032231pt_PT
dc.relationConsequence of mother`s behavior on offspring cognition abolily: the role of environment manipulation as strategy to reduce maternal anxiety
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-020-70242-4.pdfpt_PT
dc.subjectConditioned place preferencept_PT
dc.subjectComorbid substance usept_PT
dc.subjectElevated plus-mazept_PT
dc.subjectMaternal separationpt_PT
dc.subjectMajor depressionpt_PT
dc.subjectCocainept_PT
dc.titleEarly-life stress affects drug abuse susceptibility in adolescent rat model independently of depression vulnerabilitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleConsequence of mother`s behavior on offspring cognition abolily: the role of environment manipulation as strategy to reduce maternal anxiety
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FSAU-TOX%2F32231%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F114266%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00753%2F2014%2FCP1241%2FCT0005/PT
oaire.citation.issue1pt_PT
oaire.citation.startPage13326pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStreamInvestigador FCT
person.familyNameSummavielle
person.givenNameTeresa
person.identifier677706
person.identifier.ciencia-idC41E-0816-5C85
person.identifier.orcid0000-0003-2548-6281
person.identifier.ridC-9776-2012
person.identifier.scopus-author-id6603092949
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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