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Detection of physiological changes in knee cartilage using parametric T2 relaxation maps estimated with a dictionary method

2025-08-23Artigo científico Acesso embargado
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dc.contributor.authorCoelho, José M.
dc.contributor.authorFernandes, Tiago T.
dc.contributor.authorAlves, Sandra M.
dc.contributor.authorVilaça, Adélio
dc.contributor.authorNunes, Rita G.
dc.contributor.authorNogueira, Luísa
dc.contributor.authorOliveira, António
dc.contributor.authorNogueira, Luisa
dc.contributor.authorAlves, Sandra Maria
dc.date.accessioned2026-05-29T14:28:32Z
dc.date.available2026-05-29T14:28:32Z
dc.date.issued2025-08-23
dc.description.abstractTo investigate half-marathon running and recovery effects on knee articular cartilage (KAC) health in athletes, using dictionary-matching T2 maps, to detect changes and recovery patterns in KAC. Eleven asymptomatic volunteers (4 females, 7 males; mean age 40 ± 5 years, mean BMI 22.7 ± 1.4 kg/m2) completed a fixed-pace half-marathonwere studied. All were right-knee dominant and engaged in regular running. Sagittal T2-weighted Multi-Echo Spin-Echo images at 3 T were used to assess T2 values pre-run, post-run, and one week later for global and compartmental KAC. Recovery programme included low-intensity running, strength training and rest. Repeated measures ANOVA or equivalent non-parametric tests with post-hoc comparisons compared T2 values over time. Separate analyses were conducted based on laterality, gender and anatomical compartments. Significance was set at < 0.05. Post-run T2 values decreased significantly by 0.9 ms (− 2.0%, p < 0.001), with up to 5.3% reductions in medial tibial (MT) and femoral (MF) compartments. Recovery patterns varied by compartment, sex and laterality. Most compartments returned to baseline within one week; the lateral condyle (LatC) showed incomplete recovery (− 4.7%, Proportional Recovery Index (PRI) = − 0,1); the right knee’s MT exhibited overcompensation (6.3%, PRI = 2.6). Males showed higher baseline T2 values and more efficient recovery in the LatC compared to females (PRI = − 0.1 vs. − 0.4). Half-marathon running induces reversible reductions in KAC hydration, with most compartments recovering or overcompensating within one week. Dictionary-matching T2 mapping offers a robust approach for monitoring cartilage integrity and guiding individualised recovery strategies.eng
dc.identifier.citationCoelho, J. M., Fernandes, T. T., Alves, S. M., Vilaça, A., Nunes, R. G., Nogueira, L., & Oliveira, A. (2026). Detection of physiological changes in knee cartilage using parametric T2 relaxation maps estimated with a dictionary method. European Journal of Applied Physiology, 126(2), 811–824. https://doi.org/10.1007/s00421-025-05898-9
dc.identifier.doi10.1007/s00421-025-05898-9
dc.identifier.eissn1439-6327
dc.identifier.issn1439-6319
dc.identifier.urihttp://hdl.handle.net/10400.22/32472
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Nature
dc.relation10. 54499/ LA/P/ 0083/ 2020; 10. 54499/ UIDP/ 50009/ 2020, and 2020. 05080.BD
dc.relation.hasversionhttps://link.springer.com/article/10.1007/s00421-025-05898-9
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectKnee articular cartilage
dc.subjectT2 mapping
dc.subjectDictionary matching
dc.subjectRunning
dc.subjectRecovery
dc.subjectOvertraining syndrome
dc.titleDetection of physiological changes in knee cartilage using parametric T2 relaxation maps estimated with a dictionary methodeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage824
oaire.citation.startPage811
oaire.citation.titleEuropean Journal of Applied Physiology
oaire.citation.volume126
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameNogueira
person.familyNameAlves
person.givenNameLuisa
person.givenNameSandra Maria
person.identifier2571691
person.identifier.ciencia-idCF1F-D1D5-6BC1
person.identifier.orcid0000-0002-1291-9490
person.identifier.orcid0000-0002-2318-7491
relation.isAuthorOfPublicationc2991b07-7696-4d2b-ad5d-863790e33130
relation.isAuthorOfPublicationf91e1151-4aad-4af3-9fef-970548be5f0c
relation.isAuthorOfPublication.latestForDiscoveryc2991b07-7696-4d2b-ad5d-863790e33130

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