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The neuroprotective effect of traditional chinese medicinal plants—A critical review

2023-08-18Journal article Open access
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dc.contributor.authorMoreira, João
dc.contributor.authorMachado, Mariana
dc.contributor.authorDias-Teixeira, Mónica
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorGrosso, Clara
dc.date.accessioned2024-03-18T15:43:56Z
dc.date.available2024-03-18T15:43:56Z
dc.date.issued2023-08-18
dc.description.abstractNeurodegenerative and neuropsychiatric diseases are increasingly affecting individuals’ quality of life, thus increasing their cost to social and health systems. These diseases have overlapping mechanisms, such as oxidative stress, protein aggregation, neuroinflammation, neurotransmission impairment, mitochondrial dysfunction, and excitotoxicity. Currently, there is no cure for neurodegenerative diseases, and the available therapies have adverse effects and low efficacy. For neuropsychiatric disorders, such as depression, the current therapies are not adequate to one-third of the patients, the so-called treatmentresistant patients. So, searching for new treatments is fundamental. Medicinal plants appear as a strong alternative and complement towards new treatment protocols, as they have been used for health purposes for thousands of years. Thus, the main goal of this review is to revisit the neuroprotective potential of some of the most predominant medicinal plants (and one fungus) used in traditional Chinese medicine (TCM), focusing on their proven mechanisms of action and their chemical compositions, to give clues on how they can be useful against neurodegeneration progression.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMoreira, J., Machado, M., Dias-Teixeira, M., Ferraz, R., Delerue-Matos, C., & Grosso, C. (2023). The neuroprotective effect of traditional chinese medicinal plants—A critical review. Acta Pharmaceutica Sinica B, 13(8), 3208–3237. https://doi.org/10.1016/j.apsb.2023.06.009pt_PT
dc.identifier.doi10.1016/j.apsb.2023.06.009pt_PT
dc.identifier.eissn2211-3843
dc.identifier.issn2211-3835
dc.identifier.urihttp://hdl.handle.net/10400.22/25183
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationThis work was supported by projects REQUIMTE/LAQV-UIDB/ 50006/2020, UIDP/50006/2020, and LA/P/0008/2020 financed by FCT/Ministe´rio da Cieˆncia, Tecnologia e Ensino Superior (MCTES), through national funds. Clara Grosso (CEECIND/ 03436/2020) thanks FCT for funding.pt_PT
dc.relation.publisherversionhttps://doi.org/10.1016/j.apsb.2023.06.009pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectNeurodegenerationpt_PT
dc.subjectAlzheimer's diseasept_PT
dc.subjectParkinson's diseasept_PT
dc.subjectDepressionpt_PT
dc.subjectMedicinal plantspt_PT
dc.subjectOxidative stresspt_PT
dc.subjectToxicologypt_PT
dc.subjectClinical trialspt_PT
dc.titleThe neuroprotective effect of traditional chinese medicinal plants—A critical reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage3237pt_PT
oaire.citation.startPage3208pt_PT
oaire.citation.titleActa Pharmaceutica Sinica Bpt_PT
oaire.citation.volume13 (8)pt_PT
person.familyNameFerraz
person.givenNameRicardo
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.orcid0000-0002-1761-117X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication.latestForDiscoverya5a8faa7-12a5-4b1c-bced-44c895677397

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