Publication
Norhierridin B, a New Hierridin B-Based Hydroquinone with Improved Antiproliferative Activity
| dc.contributor.author | Brandão, Pedro | |
| dc.contributor.author | Moreira, Joana | |
| dc.contributor.author | Almeida, Joana | |
| dc.contributor.author | Nazareth, Nair | |
| dc.contributor.author | Sampaio-Dias, Ivo E. | |
| dc.contributor.author | Vasconcelos, Vítor | |
| dc.contributor.author | Martins, Rosario | |
| dc.contributor.author | Leão, Pedro | |
| dc.contributor.author | Pinto, Madalena | |
| dc.contributor.author | Saraíva, Lucília | |
| dc.contributor.author | Cidade, Honorina | |
| dc.date.accessioned | 2020-03-30T15:16:08Z | |
| dc.date.available | 2020-03-30T15:16:08Z | |
| dc.date.issued | 2020-03 | |
| dc.description.abstract | Hierridin B (6), a methylated hydroquinone isolated from the marine picocyanobacterium Cyanobium sp. LEGE 06113, moderately inhibited the growth of colon adenocarcinoma HT-29 cells. Aiming to improve the potential antitumor activity of this natural product, the demethylated analogue, norhierridin B (10), as well as its structurally-related quinone (9), were synthesized and evaluated for their growth inhibitory effect on a panel of human tumor cell lines, including the triple-negative breast cancer (TNBC) cells MDA-MB-231, SKBR3, and MDA-MB-468. Norhierridin B (10) showed a potent growth inhibitory effect on all cancer cell lines. Moreover, the growth inhibitory effect of compound 10 on MDA-MB-231 cells was associated with cell cycle arrest and apoptosis. Norhierridin B (10) interfered with several p53 transcriptional targets, increasing p21, Bax, and MDM2, while decreasing Bcl-2 protein levels, which suggested the potential activation of a p53 pathway. Altogether, these results evidenced a great improvement of the antitumor activity of hydroquinone 10 when compared to 6 and its structurally-related quinone (9). Notably, hydroquinone 10 displayed a prominent growth inhibitory activity against TNBC cells, which are characterized by high therapeutic resistance. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.3390/molecules25071578 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.22/15674 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.relation.publisherversion | https://www.mdpi.com/1420-3049/25/7/1578 | pt_PT |
| dc.subject | Antitumor activity | pt_PT |
| dc.subject | Hierridin B | pt_PT |
| dc.subject | Hydroquinones | pt_PT |
| dc.subject | Quinones | pt_PT |
| dc.title | Norhierridin B, a New Hierridin B-Based Hydroquinone with Improved Antiproliferative Activity | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 7 | pt_PT |
| oaire.citation.title | Molecules | pt_PT |
| oaire.citation.volume | 25 | pt_PT |
| person.familyName | Martins | |
| person.givenName | Rosario | |
| person.identifier.ciencia-id | A919-DB40-EF10 | |
| person.identifier.orcid | 0000-0002-9882-4651 | |
| person.identifier.scopus-author-id | 21834368700 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | 82a7c349-c88e-450f-adc7-3331d69149cf | |
| relation.isAuthorOfPublication.latestForDiscovery | 82a7c349-c88e-450f-adc7-3331d69149cf |