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Genotoxicity of gold nanoparticles in the gilthead seabream (Sparus aurata) after single exposure and combined with the pharmaceutical gemfibrozil

2019Journal article Open access
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dc.contributor.authorBarreto, A.
dc.contributor.authorLuis, L.G.
dc.contributor.authorPinto, E.
dc.contributor.authorAlmeida, A.
dc.contributor.authorPaíga, Paula
dc.contributor.authorH.M.L.M. Santos, Lúcia
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorTrindade, T.
dc.contributor.authorSoares, A.M.V.M.
dc.contributor.authorHylland, K.
dc.contributor.authorLoureiro, S.
dc.contributor.authorOliveira, M.
dc.date.accessioned2019-04-18T11:25:00Z
dc.date.available2019-04-18T11:25:00Z
dc.date.issued2019
dc.description.abstractDue to their diverse applications, gold nanoparticles (AuNPs) are expected to increase of in the environment, although few studies are available on their mode of action in aquatic organisms. The genotoxicity of AuNPs, alone or combined with the human pharmaceutical gemfibrozil (GEM), an environmental contaminant frequently detected in aquatic systems, including in marine ecosystems, was examined using gilthead seabream erythrocytes as a model system. Fish were exposed for 96 h to 4, 80 and 1600 μg L-1 of 40 nm AuNPs with two coatings - citrate or polyvinylpyrrolidone; GEM (150 μg L-1); and a combination of AuNPs and GEM (80 μg L-1 AuNPs + 150 μg L-1 GEM). AuNPs induced DNA damage and increased nuclear abnormalities levels, with coating showing an important role in the toxicity of AuNPs to fish. The combined exposures of AuNPs and GEM produced an antagonistic response, with observed toxic effects in the mixtures being lower than the predicted. The results raise concern about the safety of AuNPs and demonstrate interactions between them and other contaminants.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.chemosphere.2018.12.090pt_PT
dc.identifier.issn1383-5718
dc.identifier.urihttp://hdl.handle.net/10400.22/13653
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationFCOMP-01-0124-FEDER-029435pt_PT
dc.relationPOCI-01-0145-FEDER-00763pt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1383571816303862?via%3Dihubpt_PT
dc.subjectAnimalspt_PT
dc.subjectAquatic Organismspt_PT
dc.subjectDNA Damagept_PT
dc.subjectDrug Interactionspt_PT
dc.subjectErythrocytespt_PT
dc.subjectGemfibrozilpt_PT
dc.subjectGoldpt_PT
dc.subjectHumanspt_PT
dc.subjectMetal Nanoparticlespt_PT
dc.subjectSea Breampt_PT
dc.subjectMutagenspt_PT
dc.titleGenotoxicity of gold nanoparticles in the gilthead seabream (Sparus aurata) after single exposure and combined with the pharmaceutical gemfibrozilpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PTDC%2FMAR-EST%2F3399%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAMB%2F50017%2F2013/PT
oaire.citation.endPage19pt_PT
oaire.citation.startPage11pt_PT
oaire.citation.titleMutation Research - Genetic Toxicology and Environmental Mutagenesispt_PT
oaire.citation.volume220pt_PT
oaire.fundingStreamCOMPETE
oaire.fundingStream5876
person.familyNamePaíga
person.familyNameSantos
person.familyNameDelerue-Matos
person.givenNamePaula
person.givenNameLúcia
person.givenNameCristina
person.identifier1668889
person.identifier554739
person.identifier.ciencia-id331A-5D6A-D3C8
person.identifier.ciencia-id201F-83C4-2FAF
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0002-9593-1355
person.identifier.orcid0000-0002-7013-8852
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridQ-4930-2018
person.identifier.ridK-6784-2013
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id6506638953
person.identifier.scopus-author-id55947204900
person.identifier.scopus-author-id6603741848
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4a0677dc-0b54-4831-aa9a-4a73f0df911d
relation.isAuthorOfPublication55aca6a3-11aa-4e3e-868b-dce605cd585e
relation.isAuthorOfPublication09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isAuthorOfPublication.latestForDiscovery55aca6a3-11aa-4e3e-868b-dce605cd585e
relation.isProjectOfPublicationa8963419-3e1e-40c4-bf46-6e981f90fda5
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