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Evaluation of the biological potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) setchell subcritical water extracts

2022-03-03Journal article Open access
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dc.contributor.authorGomes, Inês
dc.contributor.authorRodrigues, Helena
dc.contributor.authorRodrigues, Carla
dc.contributor.authorMarques, Marta
dc.contributor.authorPaíga, Paula
dc.contributor.authorPaiva, Alexandre
dc.contributor.authorSimões, Pedro
dc.contributor.authorCruz Fernandes, Virgínia
dc.contributor.authorVieira, Mónica
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorSoares, Cristina
dc.contributor.authorGrosso, Clara
dc.date.accessioned2022-05-19T15:37:53Z
dc.date.available2022-05-19T15:37:53Z
dc.date.issued2022-03-03
dc.description.abstractNeuroprotection is a need that remains unmet in treating chronic neurodegenerative disorders, despite decades of extensive research. To find new neuroprotective compounds, extracts of Himanthalia elongata (L.) S.F.Gray and of Eisenia bicyclis (Kjellman) Setchell were obtained through subcritical water extraction applying a four-step temperature gradient. The fractions obtained were screened against brain enzymes involved in neurodegenerative etiology, namely in Alzheimer’s and Parkinson’s diseases, and against reactive oxygen and nitrogen species, all contributing factors to the progression of neurodegeneration. Results showed no significant enzyme inhibition but strong radical scavenging activities, particularly in the fourth fraction, extracted at the highest temperature (250 °C), highlighting their ability to retard oxidative and nitrosative stresses. At higher temperatures, fractions were composed of phenolic compounds and Maillard reaction products, a combination that contributed to their antioxidant activity and, consequently, their neuroprotective properties. All fractions were evaluated for the presence of iodine, 14 organochlorine and 7 organophosphorus pesticides, and pharmaceuticals used in Alzheimer’s and Parkinson’s diseases (14), psychiatric drugs (8), and metabolites (8). The fractions studied did not present any of the screened contaminants, and only fraction 1 of E. bicyclis should be used with caution due to iodine content.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGomes, I., Rodrigues, H., Rodrigues, C., Marques, M., Paíga, P., Paiva, A., Simões, P., Fernandes, V. C., Vieira, M., Delerue-Matos, C., Soares, C., & Grosso, C. (2022). Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts. Foods, 11(5), 746. https://www.mdpi.com/2304-8158/11/5/746pt_PT
dc.identifier.doi10.3390/foods11050746pt_PT
dc.identifier.issn2304-8158
dc.identifier.urihttp://hdl.handle.net/10400.22/20543
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2304-8158/11/5/746pt_PT
dc.subjectIodinept_PT
dc.subjectMaillard reactionpt_PT
dc.subjectNeuroprotectionpt_PT
dc.subjectNitrosative stresspt_PT
dc.subjectOxidative stresspt_PT
dc.subjectPesticidespt_PT
dc.subjectPharmaceuticalspt_PT
dc.subjectSeaweedspt_PT
dc.subjectTotal phenolic contentpt_PT
dc.titleEvaluation of the biological potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) setchell subcritical water extractspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage17pt_PT
oaire.citation.startPage2pt_PT
oaire.citation.titleFoodspt_PT
oaire.citation.volume11pt_PT
person.familyNameVieira
person.givenNameMónica
person.identifier.orcid0000-0002-9614-9031
person.identifier.ridD-8977-2016
person.identifier.scopus-author-id24464652500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication55587c4b-3df0-4ff1-bade-587420940ecd
relation.isAuthorOfPublication.latestForDiscovery55587c4b-3df0-4ff1-bade-587420940ecd

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