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QuEChERS: a new sample preparation approach for the determination of ibuprofen and its metabolites in soils

2012Journal article Open access
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dc.contributor.authorBragança, Idalina
dc.contributor.authorPlácido, Alexandra
dc.contributor.authorPaíga, Paula
dc.contributor.authorDomingues, Valentina F.
dc.contributor.authorDelerue-Matos, Cristina
dc.date.accessioned2013-10-01T11:08:18Z
dc.date.available2013-10-01T11:08:18Z
dc.date.issued2012
dc.description.abstractIbuprofen is one of the most used active pharmaceutical ingredients worldwide. A new method for the analysis of ibuprofen and its metabolites, hydroxyibuprofen and carboxyibuprofen, in soils is presented. The extraction of these compounds from the soil matrices was performed by using a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) method. The method involves a single extraction of the investigated compounds with purified water (acidified at pH 2.5 with hydrochloric acid), and a slow and continuous addition of the QuEChERS content, followed by the addition of acidified acetonitrile (1% acetic acid), prior to the determination by liquid chromatography coupled with fluorescence detection (LC–FLD). Validation studies were carried out using soil samples with a range of organic carbon contents. Recoveries of the fortified samples ranged from 79.5% to 101%. Relative standard deviations for all matrix–compound combinations did not exceed 3%. The method quantification limits were ≤22.4 μg kg−1 in all cases. The developed method was applied to the analysis of sixteen real samples.por
dc.identifier.doi10.1016/j.scitotenv.2012.06.035pt_PT
dc.identifier.issn0048-9697
dc.identifier.urihttp://hdl.handle.net/10400.22/2050
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.ispartofseriesScience of the Total Environment; Vol. 433
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0048969712008613por
dc.subjectIbuprofenpor
dc.subjectMetabolitespor
dc.subjectQuEChERSpor
dc.subjectSoilpor
dc.subjectExtractionpor
dc.titleQuEChERS: a new sample preparation approach for the determination of ibuprofen and its metabolites in soilspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage289por
oaire.citation.startPage281por
oaire.citation.titleScience of the Total Environment
oaire.citation.volumeVol. 433por
person.familyNamePaíga
person.familyNameDomingues
person.familyNameDelerue-Matos
person.givenNamePaula
person.givenNameValentina Maria Fernandes
person.givenNameCristina
person.identifier1668889
person.identifier.ciencia-id331A-5D6A-D3C8
person.identifier.ciencia-id4E16-791D-6664
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0002-9593-1355
person.identifier.orcid0000-0003-3472-849X
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridQ-4930-2018
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id6506638953
person.identifier.scopus-author-id6603741848
rcaap.rightsclosedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication4a0677dc-0b54-4831-aa9a-4a73f0df911d
relation.isAuthorOfPublicationbe653ab6-34ec-4329-972a-eee990a7ec66
relation.isAuthorOfPublication09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isAuthorOfPublication.latestForDiscoverybe653ab6-34ec-4329-972a-eee990a7ec66

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