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The magic cocktail: Ampicillin and Biosynthesized gold nanoparticles synergism against Staphylococcus aureus

2023-10-03Journal article Open access
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dc.contributor.authorOliveira, Marco
dc.contributor.authorSoares, Sílvia
dc.contributor.authorSá, Sara
dc.contributor.authorGestoso, Álvaro
dc.contributor.authorCorrea-Duarte, Miguel
dc.contributor.authorBaylina, Pilar
dc.contributor.authorFernandes, Rúben
dc.contributor.authorPereira, Carla F.
dc.date.accessioned2024-04-08T14:09:25Z
dc.date.available2024-04-08T14:09:25Z
dc.date.issued2023-10-03
dc.description.abstractGold nanoparticles (AuNPs) have garnered attention as a potential alternative to conventional antibiotics due to their innovative antibacterial properties. This study demonstrates the successful production of biosynthetic gold nanoparticles (bAuNPs) using Pseudomonas aeruginosa (P. aeruginosa) as spherical nanostructures at 58 ◦C for 24 h, under alkaline pH (9.0). The successful synthesis of bAuNPs was confirmed through UV-Vis spectroscopy, exhibiting a characteristic peak within the 500–600 nm wavelength range, and the evaluation of the main functional groups and morphology were stressed by Fourier Transform Infrared Spectroscopy (FT-IR) and Transmission Electron Microscopy (TEM), respectively. Subsequently, the synthesized bAuNPs were combined with low concentrations of ampicillin and evaluated against Methicillin-Susceptible Staphylococcus aureus (MSSA) and Methicillin-Resistant Staphylococcus aureus (MRSA) through the classical serial dilution method. This innovative approach holds the potential to address the escalating issue of antibiotic resistance, providing a viable and sustainable solutionpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOliveira, M., Soares, S., Sá, S., Gestoso, Á., Correa-Duarte, M., Baylina, P., Fernandes, R., & Pereira, C. F. (2023). The magic cocktail: Ampicillin and Biosynthesized gold nanoparticles synergism against Staphylococcus aureus. Applied Sciences, 13(19), Artigo 19. https://doi.org/10.3390/app131910934pt_PT
dc.identifier.doi10.3390/app131910934pt_PT
dc.identifier.eissn2076-3417
dc.identifier.urihttp://hdl.handle.net/10400.22/25306
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationR.F. and P.B. acknowledges on the behalf of the authors the support of FCT (Strategic Project Reference: UID/BIM/04293/2013. R.F. and P.B. ware also supported by FEDER/02/SAICT/2020/072560. M.O. was funded by LaBMI, grant number PORTIC/IPP4COVID/BI/2021/01.pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2076-3417/13/19/10934pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntibiotic resistancept_PT
dc.subjectBiosynthetic gold nanoparticlespt_PT
dc.subjectAmpicillinpt_PT
dc.subjectSynergismpt_PT
dc.titleThe magic cocktail: Ampicillin and Biosynthesized gold nanoparticles synergism against Staphylococcus aureuspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage13pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleApplied Sciencespt_PT
oaire.citation.volume13(19)pt_PT
person.familyNameBAYLINA MACHADO
person.givenNamePILAR
person.identifier.ciencia-id1419-F23D-4920
person.identifier.orcid0000-0002-3740-862X
person.identifier.ridB-5134-2010
person.identifier.scopus-author-id56534079700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb1482a24-d9d8-419d-af68-6df1a75afb3f
relation.isAuthorOfPublication.latestForDiscoveryb1482a24-d9d8-419d-af68-6df1a75afb3f

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