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The influence of miRNAs on radiotherapy treatment in prostate cancer – a systematic review

2021-08-03Journal article Open access
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dc.contributor.authorSoares, Sílvia
dc.contributor.authorGuerreiro, Susana S.
dc.contributor.authorCruz-Martins, Natália
dc.contributor.authorSousa Pinho Faria, Isabel Maria
dc.contributor.authorBaylina, Pilar
dc.contributor.authorSales, Maria Goretti
dc.contributor.authorCorrea-Duarte, Miguel A.
dc.contributor.authorFernandes, Rúben
dc.date.accessioned2021-09-23T11:04:52Z
dc.date.available2021-09-23T11:04:52Z
dc.date.issued2021-08-03
dc.description.abstractIn the last years, extensive investigation on miRNomics have shown to have great advantages in cancer personalized medicine regarding diagnosis, treatment and even clinical outcomes. Prostate cancer (PCa) is the second most common male cancer and about 50% of all PCa patients received radiotherapy (RT), despite some of them develop radioresistance. Here, we aim to provide an overview on the mechanisms of miRNA biogenesis and to discuss the functional impact of miRNAs on PCa under radiation response. As main findings, 23 miRNAs were already identified as being involved in genetic regulation of PCa cell response to RT. The mechanisms of radioresistance are still poorly understood, despite it has been suggested that miRNAs play an important role in cell signaling pathways. Identification of miRNAs panel can be thus considered an upcoming and potentially useful strategy in PCa diagnosis, given that radioresistance biomarkers, in both prognosis and therapy still remains a challenge.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSoares S, Guerreiro SG, Cruz-Martins N, Faria I, Baylina P, Sales MG, Correa-Duarte MA and Fernandes R (2021) The Influence of miRNAs on Radiotherapy Treatment in Prostate Cancer – A Systematic Review. Front. Oncol. 11:704664. doi: 10.3389/fonc.2021.704664pt_PT
dc.identifier.doi10.3389/fonc.2021.704664pt_PT
dc.identifier.issn2234-943X
dc.identifier.urihttp://hdl.handle.net/10400.22/18502
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fonc.2021.704664/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectProstate cancerpt_PT
dc.subjectRadiotherapypt_PT
dc.subjectRNA therapypt_PT
dc.subjectMmicroRNApt_PT
dc.subjectOncomiRpt_PT
dc.subjectOncosupressor mipt_PT
dc.titleThe influence of miRNAs on radiotherapy treatment in prostate cancer – a systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage14pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFrontiers in Oncologypt_PT
person.familyNameSousa Pinho Faria
person.familyNameBAYLINA MACHADO
person.familyNameCorrea-Duarte
person.givenNameIsabel Maria
person.givenNamePILAR
person.givenNameMiguel A.
person.identifier81160
person.identifier.ciencia-id1419-F23D-4920
person.identifier.ciencia-id531D-D97E-5153
person.identifier.orcid0000-0002-1467-7800
person.identifier.orcid0000-0002-3740-862X
person.identifier.orcid0000-0003-1950-1414
person.identifier.ridB-5134-2010
person.identifier.scopus-author-id56534079700
person.identifier.scopus-author-id23488450500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb74bdeca-0113-40a8-ba5a-8fe2d558fe0e
relation.isAuthorOfPublicationb1482a24-d9d8-419d-af68-6df1a75afb3f
relation.isAuthorOfPublication540d135d-7e45-4f17-a975-0820805046f3
relation.isAuthorOfPublication.latestForDiscoveryb1482a24-d9d8-419d-af68-6df1a75afb3f

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