Publication
Adult asthma scoresādevelopment and validation of multivariable scores to identify asthma in surveys
| dc.contributor.author | SĆ”-Sousa, Ana | |
| dc.contributor.author | Pereira, Ana Margarida | |
| dc.contributor.author | Almeida, Rute | |
| dc.contributor.author | AraĆŗjo, LuĆs | |
| dc.contributor.author | Couto, Mariana | |
| dc.contributor.author | Jacinto, Tiago | |
| dc.contributor.author | Freitas, Alberto | |
| dc.contributor.author | Bousquet, Jean | |
| dc.contributor.author | Fonseca, JoĆ£o A. | |
| dc.date.accessioned | 2019-06-13T16:34:07Z | |
| dc.date.available | 2020-02-02T01:30:31Z | |
| dc.date.issued | 2019-01 | |
| dc.description.abstract | One of the questions in epidemiology is the identification of adult asthma in studies. To develop and validate multivariable scores for adult asthma identification in epidemiological studies and to explore cutoffs to rule in/rule out asthma, compared with asthma diagnosed by a physician after clinical examination and diagnostic tests, blinded to the self-administered questions. We analyzed data (n = 711 adults) from a nationwide population-based study. The predictors were self-administered questions identified in a literature review (the Adult Asthma Epidemiological Score [A2 score]) and from the Global Allergy and Asthma Network of Excellence (GA2LEN) questionnaire (the GA2LEN Asthma Epidemiological Score [GA2LEN score]). Scores were developed using exploratory factor analysis. Internal consistency, discriminative power, and diagnostic accuracy were assessed. The A2 score comprises 8 questions (including āDid a physician confirm you had asthma?ā) and the GA2LEN score comprises 6 questions (including āHave you ever had asthma?ā). Both had high Cronbach Ī± (0.89 and 0.85, respectively, for the A2 score and the GA2LEN score) and good area under the receiver-operating characteristic curve (90.4% and 89.0%). The scoring is the sum of positive answers. Asthma is present (rule in) for scores of 4 or more (specificity, 99.2%; PPV, 93.3% and 91.7%; accuracy, 89.4% and 87.4%, respectively, for the A2 score and the GA2LEN score). Asthma is excluded (rule out) for A2 scores of 0 to 1 and a GA2LEN score of 0 (sensitivity, 93.1%; NPV, 98.2% and 98.0%; accuracy 89.4% and 82.8%, respectively, for the A2 score and the GA2LEN score). These practical scores can be used to rule in/rule out asthma in epidemiological studies and clinical screening/triage settings. They may help physicians in primary care or other specialties to screen patients with asthma using a simple score with a high level of discrimination and to identify the best candidates to be referred for a diagnostic workup. Moreover, their use may contribute to reducing the inconsistencies of operational definitions of asthma across studies and surveys. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | SĆ”-Sousa, A., Pereira, A. M., Almeida, R., AraĆŗjo, L., Couto, M., Jacinto, T., Freitas, A., Bousquet, J., & Fonseca, J. A. (2019). Adult Asthma ScoresāDevelopment and Validation of Multivariable Scores to Identify Asthma in Surveys. The Journal of Allergy and Clinical Immunology: In Practice, 7(1), 183-190.e6. https://doi.org/10.1016/j.jaip.2018.06.024 | |
| dc.identifier.doi | 10.1016/j.jaip.2018.06.024 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.22/13997 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.relation | PD/0003/2013 | pt_PT |
| dc.relation | Identifying people with anaphylaxis and Asthma-from criteria definition and validation to the implementation of clinical alerts in an electronic Health Record. - Contributions to identify asthma and patients with future risk of adverse outcomes | |
| dc.relation.publisherversion | https://www.jaci-inpractice.org/article/S2213-2198(18)30428-8/fulltext | pt_PT |
| dc.subject | Asthma | pt_PT |
| dc.subject | Epidemiology | pt_PT |
| dc.subject | Validation studies | pt_PT |
| dc.subject | Factor analysis | pt_PT |
| dc.subject | Questionnaire survey | pt_PT |
| dc.title | Adult asthma scoresādevelopment and validation of multivariable scores to identify asthma in surveys | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Identifying people with anaphylaxis and Asthma-from criteria definition and validation to the implementation of clinical alerts in an electronic Health Record. - Contributions to identify asthma and patients with future risk of adverse outcomes | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//PD%2FBD%2F113665%2F2015/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/COMPETE/PTDC%2FSAU-SAP%2F119192%2F2010/PT | |
| oaire.citation.endPage | 190.e6 | pt_PT |
| oaire.citation.issue | 1 | pt_PT |
| oaire.citation.startPage | 183 | pt_PT |
| oaire.citation.title | Journal of Allergy and Clinical Immunology: In Practice | pt_PT |
| oaire.citation.volume | 7 | pt_PT |
| oaire.fundingStream | COMPETE | |
| person.identifier.ciencia-id | ED1E-5481-48E1 | |
| person.identifier.orcid | 0000-0002-7897-1101 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | FundaĆ§Ć£o para a CiĆŖncia e a Tecnologia | |
| project.funder.name | FundaĆ§Ć£o para a CiĆŖncia e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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