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MDA in adolescent male rats - decreased serotonin in the amygdala and behavioral effects in the elevated plus-maze test

2006-09-06Journal article Open access
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dc.contributor.authorFaria, Raquel
dc.contributor.authorMagalhães, Ana
dc.contributor.authorMonteiro, Pedro
dc.contributor.authorSilva, Joana Gomes da
dc.contributor.authorTavares, Maria Amélia
dc.contributor.authorSummavielle, Teresa
dc.date.accessioned2021-09-28T07:54:40Z
dc.date.available2021-09-28T07:54:40Z
dc.date.issued2006-09-06
dc.description.abstractLong-term behavioral consequences of the neurotoxicity produced by 3,4-methylenedioxymethamphetamine (MDMA) in the adolescent rat are still mostly unknown. Here, adolescent male rats (postnatal day 45 PND [45]) were exposed to 10 mg/kg of MDMA, intraperitoneally, every 2 h for 6 h. Controls were given 0.9% saline in the same protocol. Ten days after exposure, the behavioral effects of MDMA were assessed in the elevated plus-maze (n = 6 per group). After behavioral testing, animals were sacrificed and the amygdalae were dissected and processed for HPLC determination of dopamine (DA), serotonin (5-HT), and metabolites. Results showed a significant decrease in the 5-HT content (P < 0.05), but no significant alterations in DA or its metabolites. Behavioral observation in the elevated plus-maze showed a decreased number of entries in the unprotected arms (P < 0.05), which were correlated to the number of entries and time spent in the central platform. Rearing was also decreased (P < 0.05). No differences were observed in head dips, grooming, or number of entries in the protected arms of the apparatus. Therefore, we conclude that, as in the adult rat, exposure to MDMA in the adolescent rat is associated to long-term depletion of the 5-HT content and increased anxiety-like behavior.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFaria, R., Magalhães, A., Monteiro, P. R. R., Gomes-da-Silva, J., Tavares, M. A., & Summavielle, T. (2006). MDMA in adolescent male rats. Annals of the New York Academy of Sciences, 1074(1), 643-649. https://doi.org/https://doi.org/10.1196/annals.1369.062pt_PT
dc.identifier.doi10.1196/annals.1369.062pt_PT
dc.identifier.issn1749-6632
dc.identifier.urihttp://hdl.handle.net/10400.22/18581
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttps://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1196/annals.1369.062pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMDMApt_PT
dc.subjectEcstasypt_PT
dc.subjectSerotoninpt_PT
dc.subjectDopaminept_PT
dc.subjectAmygdalapt_PT
dc.subjectAnxietypt_PT
dc.titleMDA in adolescent male rats - decreased serotonin in the amygdala and behavioral effects in the elevated plus-maze testpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage649pt_PT
oaire.citation.startPage643pt_PT
oaire.citation.titleAnnals of the New York Academy of Sciencespt_PT
oaire.citation.volume1074pt_PT
person.familyNameMonteiro
person.familyNameSummavielle
person.givenNamePedro
person.givenNameTeresa
person.identifier677706
person.identifier.ciencia-id2414-4468-928B
person.identifier.ciencia-idC41E-0816-5C85
person.identifier.orcid0000-0002-3991-9191
person.identifier.orcid0000-0003-2548-6281
person.identifier.ridC-9776-2012
person.identifier.scopus-author-id6504494827
person.identifier.scopus-author-id6603092949
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationfae8b5b3-db39-4d56-a2b1-2db0388279b9
relation.isAuthorOfPublication207ee2de-85a0-4144-9e7e-b376c600e065
relation.isAuthorOfPublication.latestForDiscovery207ee2de-85a0-4144-9e7e-b376c600e065

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