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Interventions to chemotherapy and radiotherapy induced oral mucositis: A Systematic Review and Meta-analysis
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Orientador(es)
Resumo(s)
Oral mucositis is a common adverse effect of chemotherapy and radiotherapy, characterized by erythematous lesions, edema, ulceration, atrophy, or even hemorrhage. Current evidence highlights the complexity of its management and the importance of tailoring therapeutic approaches to the individual patient profile in order to improve quality of life during cancer treatment. To access the efficacy of pharmacological and non-pharmacological interventions for the prevention and treatment of chemotherapy- and/or radiotherapy-induced oral mucositis. A systematic review with meta-analysis of 27 articles published between 2019 and 2024 was also performed, aiming to characterize and contextualize therapeutic interventions for oral mucositis. This systematic review and meta-analysis suggests that various non-pharmacological interventions (such as cryotherapy and photobiomodulation) and pharmacological interventions, particularly natural agents (such as honey, curcumin, green tea), are effective for the prevention and treatment of oral mucositis. Oral mucositis is a highly prevalent adverse effect in patients undergoing chemotherapy and/or radiotherapy, with significant functional, nutritional, and treatment adherence implications. The systematic review with meta-analysis demonstrated the efficacy of non-pharmacological and natural interventions.
Descrição
Palavras-chave
Chemotherapy Curcuma Drug therapy Herbal teas Honey MeSH Terms: Stomatitis Non-pharmacological interventions Oral mucositis Pharmacologic actions Pharmacological treatment Radiotherapy
Contexto Educativo
Citação
Pereira, C. P., Marques, I., & Martins, J. P. (2025). Interventions to chemotherapy and radiotherapy induced oral mucositis: A Systematic Review and Meta-analysis. Acta Stomatologica Croatica, 54(9), 389–409. https://doi.org/10.15644/asc59/4/6
Editora
ASCRO