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Safeguarding patients, relatives, and nurses: A screening approach for detecting 5-FU residues on elastomeric infusion pumps using HPLC-DAD

2025-05-21Research article Open access
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dc.contributor.authorCardoso, Andreia
dc.contributor.authorJesus, Ângelo
dc.contributor.authorBarreiros, Luísa
dc.contributor.authorCarvalho, Daniel
dc.contributor.authorSá, Maria dos Anjos
dc.contributor.authorCarvalho, Susana
dc.contributor.authorCorreia, Patrícia
dc.contributor.authorMoreira, Fernando
dc.contributor.authorMoreira, Fernando
dc.contributor.authorCorreia, Patrícia Carla dos Santos
dc.contributor.authorBarreiros, Luisa
dc.contributor.authorJesus, Ângelo
dc.date.accessioned2025-11-06T11:36:46Z
dc.date.available2025-11-06T11:36:46Z
dc.date.issued2025-05-21
dc.description.abstractThe leakage of 5-fluorouracil (5-FU) from elastomeric infusion pumps used in cancer therapy poses a potential risk of unintentional exposure to multiple individuals, including patients’ relatives and healthcare professionals, and may also compromise the accurate administration of 5-FU dosages to patients. This study aimed to develop, validate, and apply an analytical method to detect and quantify 5-FU residues on the external surfaces of infusion pumps. A high-performance liquid chromatography with diode-array detection (HPLC-DAD) method was optimized for the quantification of 5-FU contamination across different components of the infusion pump, including the hard casing, infusion tubing, and catheter connection port. A mobile phase containing 5% acetic acid was used to obtain more efficient separation of 5-FU and the detection was performed at 260 nm. The method was evaluated for linearity, sensitivity, precision, accuracy, selectivity, robustness, and stability. The method demonstrated linearity within the range of 0.150 to 3.000 µg/cm2, with limits of detection and quantification of 0.05 µg/cm2 and 0.14 µg/cm2, respectively. Relative standard deviations ranged from 1.8% to 12.7%, and accuracy exceeded 85%. In real sample analysis, detectable residues were found around the catheter connection port. This screening-oriented method addresses an existing gap, as previous contamination reports were based solely on self-reported user observations. The detection of 5-FU residues highlights the critical need for safe handling practices and the consistent use of personal protective equipment (PPE) to protect healthcare workers, especially nursing staff involved in the removal of the infusion pumps, after treatment.por
dc.identifier.citationCardoso, A., Jesus, Â., Barreiros, L., Carvalho, D., Sá, M. dos A., Carvalho, S., Correia, P., & Moreira, F. (2025). Safeguarding Patients, Relatives, and Nurses: A Screening Approach for Detecting 5-FU Residues on Elastomeric Infusion Pumps Using HPLC-DAD. Toxics, 13(5), 416. https://doi.org/10.3390/toxics13050416
dc.identifier.doi10.3390/toxics13050416
dc.identifier.eissn2305-6304
dc.identifier.urihttp://hdl.handle.net/10400.22/30756
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationUID/50006; 2022.06012.PTDC
dc.relation.hasversionhttps://www.mdpi.com/2305-6304/13/5/416
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCytotoxic
dc.subjectChemotherapy
dc.subjectAntineoplastic
dc.subject5-FU
dc.subjectHPLC-DAD
dc.subjectOccupational exposure
dc.subjectColorectal cancer
dc.titleSafeguarding patients, relatives, and nurses: A screening approach for detecting 5-FU residues on elastomeric infusion pumps using HPLC-DADpor
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.endPage19
oaire.citation.issue5
oaire.citation.startPage1
oaire.citation.titleToxics
oaire.citation.volume13
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameMoreira
person.familyNameCorreia
person.familyNameBarreiros
person.familyNameJesus
person.givenNameFernando
person.givenNamePatrícia Carla dos Santos Correia
person.givenNameLuisa
person.givenNameÂngelo
person.identifier2947760
person.identifier.ciencia-id5F16-AB92-94D0
person.identifier.ciencia-id221F-5A5F-BFC9
person.identifier.ciencia-id611F-E0C5-0230
person.identifier.ciencia-idA91F-3585-4F42
person.identifier.orcid0000-0002-3452-1459
person.identifier.orcid0000-0001-7869-7977
person.identifier.orcid0000-0003-3481-5809
person.identifier.orcid0000-0003-3972-8253
person.identifier.ridD-7950-2013
person.identifier.ridA-4404-2012
person.identifier.scopus-author-id6508205485
person.identifier.scopus-author-id56153841300
relation.isAuthorOfPublication81213e80-09a5-4655-93dc-e54199edb2fe
relation.isAuthorOfPublication655ab14f-f60f-42c5-8c8a-19d5257ff5f6
relation.isAuthorOfPublication1e66bacc-64de-4ecb-96b7-4c0e366cba57
relation.isAuthorOfPublication1cbff3da-9800-4bd7-8d84-fd8d9ca819b2
relation.isAuthorOfPublication.latestForDiscovery81213e80-09a5-4655-93dc-e54199edb2fe

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