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Publication
Adherence to treatment in allergic rhinitis during the pollen season in Europe: A MASKāair Study
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Authors
Advisor(s)
Abstract(s)
Adherence to rhinitis treatment has been insufficiently assessed. We aimed to use data from the MASK-airmHealth app to assess adherence to oral antihistamines (OAH), intra-nasal corticosteroids (INCS) or azelastine-fluticasone inpatients with allergic rhinitis. We included regular European MASK-air users with self-reported allergic rhinitis and reporting at least 1 day of OAH,INCS or azelastine-fluticasone. We assessed weeks during which patients answered the MASK-air questionnaire on all days. Werestricted our analyses to data provided between January and June, to encompass the pollen seasons across the different assessedcountries. We analysed symptoms using visual analogue scales (VASs) and the combined symptom-medication score (CSMS),performing stratified analyses by weekly adherence levels. Medication adherence was computed as the proportion of days inwhich patients reported rhinitis medication use. Sensitivity analyses were performed considering all weeks with at most 1 day ofmissing data and all months with at most 4 days of missing data. We assessed 8212 complete weeks (1361 users). Adherence (use of medication > 80% days) to specific drug classesranged from 31.7% weeks for azelastine-fluticasone to 38.5% weeks for OAH. Similar adherence to rhinitis medication was foundin users with or without self-reported asthma, except for INCS (better adherence in asthma patients). VAS and CSMS levelsincreased from no adherence to full adherence, except for INCS. A higher proportion of days with uncontrolled symptoms was observed in weeks with higher adherence. In full adherence weeks, 41.2% days reported rhinitis co-medication. The sensitivityanalyses displayed similar results. A high adherence was found in patients reporting regular use of MASK-air. Different adherence patterns werefound for INCS compared to OAH or azelastine-fluticasone that are likely to impact guidelines.
Description
Keywords
Allergic rhinitis Mobile health Treatment adherence
Citation
Sousa-Pinto, B., Costa, E. M., Vieira, R. J., Klimek, L., Czarlewski, W., Pfaar, O., Bedbrook, A., Amaral, R., Brussino, L., Kvedariene, V., Larenas-Linnemann, D. E., Iinuma, T., Pham-Thi, N., Regateiro, F. S., Taborda-Barata, L., Ventura, M. T., Ansotegui, I. J., Bergmann, K. C., Canonica, G. W., ā¦ Tank, the M. think. (2025). Adherence to treatment in allergic rhinitis during the pollen season in Europe: A MASK-air study. Clinical & Experimental Allergy, 55(3), 226ā238. https://doi.org/10.1111/cea.70004
Publisher
Wiley