Publicação
Rare but relevant: MDMA and hyponatraemia
| dc.contributor.author | Garcia, Maria Rita | |
| dc.contributor.author | Gomes, Nelson G. M. | |
| dc.contributor.author | Silva, Diana Dias da | |
| dc.contributor.author | Dias da Silva, Diana Cristina | |
| dc.date.accessioned | 2026-04-13T09:24:56Z | |
| dc.date.available | 2026-04-13T09:24:56Z | |
| dc.date.issued | 2026-03 | |
| dc.description.abstract | Conventionally used for its stimulant, empathogenic and entactogenic effects,3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is one of the most commonlyused psychoactive drugs, specifically among young adults and in nightlife and recrea-tional party contexts. Often perceived as a safe drug, MDMA can display an array oftoxic effects on multiple organs, with hyponatraemia (a low blood sodium concentrationthat can cause an altered mental state) being increasingly reported. Although hypona-traemia per se is among the most common electrolyte disorders encountered in clinicalcare, acute MDMA-induced hyponatraemia was first described in 1993 and constitutes alife-threatening condition if left untreated, particularly among women, who presenthigher incidence rates and increased odds of developing severe clinical effects. The pre-sent review outlines the main clinical manifestations and prevalence of MDMA-inducedhyponatraemia, its pathophysiological mechanisms and the therapeutical approaches tocorrect this electrolyte imbalance. | eng |
| dc.identifier.citation | Garcia, M. R., Gomes, N. G. M., & Dias-da-Silva, D. (2026). Rare but relevant: MDMA and hyponatraemia. Addiction, 121(3), 713–718. https://doi.org/10.1111/add.70255 | |
| dc.identifier.doi | https://doi.org/10.1111/add.70255 | |
| dc.identifier.eissn | 1360-0443 | |
| dc.identifier.issn | 0965-2140 | |
| dc.identifier.uri | http://hdl.handle.net/10400.22/32212 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Wiley | |
| dc.relation | UID/50006/2025 | |
| dc.relation.hasversion | https://onlinelibrary.wiley.com/doi/10.1111/add.70255 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Antidiuretic hormone (ADH) | |
| dc.subject | Arginine vasopressin (AVP) | |
| dc.subject | Ecstasy | |
| dc.subject | Electrolyte balance | |
| dc.subject | Hyperthermia | |
| dc.subject | Hyponatraemia | |
| dc.subject | Molly | |
| dc.subject | Polydipsia | |
| dc.title | Rare but relevant: MDMA and hyponatraemia | eng |
| dc.type | research article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 718 | |
| oaire.citation.issue | 3 | |
| oaire.citation.startPage | 713 | |
| oaire.citation.title | Addiction | |
| oaire.citation.volume | 121 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
| person.familyName | Dias da Silva | |
| person.givenName | Diana Cristina | |
| person.identifier.ciencia-id | 7715-CF06-F0B5 | |
| person.identifier.orcid | 0000-0002-7331-9157 | |
| relation.isAuthorOfPublication | 1f32faf1-efa5-4ea0-982d-a755e1940abf | |
| relation.isAuthorOfPublication.latestForDiscovery | 1f32faf1-efa5-4ea0-982d-a755e1940abf |