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European network on optimizing treatment with therapeutic antibodies in Chronic Inflammatory Diseases: Overview, progress and perspectives

2026-06-19Artigo de investigação Acesso aberto
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dc.contributor.authorTachkov, Konstantin
dc.contributor.authorRumano, Merita
dc.contributor.authorBluett, James
dc.contributor.authorBogavac-Stanojević, Nataša
dc.contributor.authorDreesen, Erwin
dc.contributor.authorItik, Mehmet
dc.contributor.authorKararigas, Georgios
dc.contributor.authorKawalec, Paweł
dc.contributor.authorSantos, Marlene
dc.contributor.authorSkrede, Silje
dc.contributor.authorPetrova, Guenka
dc.contributor.authorMulleman, Denis
dc.contributor.authorSantos, Marlene
dc.date.accessioned2026-07-14T09:58:25Z
dc.date.available2026-07-14T09:58:25Z
dc.date.issued2026-06-19
dc.description.abstractTreatment of chronic inflammatory diseases has been revolutionized with the introduction of targeted therapies using therapeutic antibodies. However, a large proportion of patients do not respond to treatment, or they lose response over time. To overcome this challenge, researchers have started to investigate strategies for treatment optimization, based on the development of patient stratification tools and therapeutic drug monitoring (TDM). The aim of the COST Action European Network on Optimizing Treatment with Therapeutic Antibodies in chronic inflammatory diseases (ENOTTA) is to create an interdisciplinary, pan-European network to defragment and structure scientific research in this field. Through the network, ENOTTA will facilitate the implementation of tools for patient stratification, as well as individualized (TDM-guided) approaches. These strategies should be cost-effective and provide therapeutic antibody treatment optimization for the treatment of chronic inflammatory diseases. This article highlights the key achievements of the ENOTTA consortium to date.eng
dc.description.sponsorshipEuropean Network on Optimising Treatment with Therapeutic Antibodies in chronic inflammatory diseases (ENOTTA) CA 21147
dc.identifier.citationTachkov, K., Rumano, M., Bluett, J., Bogavac-Stanojević, N., Dreesen, E., Itik, M., Kararigas, G., Kawalec, P., Santos, M., Skrede, S., Petrova, G., & Mulleman, D. (2026). European network on optimizing treatment with therapeutic antibodies in Chronic Inflammatory Diseases: Overview, progress and perspectives. Clinical and Translational Science, 19(6), e70643. https://doi.org/10.1111/cts.70643
dc.identifier.doi10.1111/cts.70643
dc.identifier.eissn1752-8062
dc.identifier.issn1752-8054
dc.identifier.urihttp://hdl.handle.net/10400.22/32591
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley/ASCPT
dc.relation.hasversionhttps://ascpt.onlinelibrary.wiley.com/doi/10.1111/cts.70643
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectChronic inflammatory diseases
dc.subjectCOST action CA21147
dc.subjectENOTTA
dc.subjectTherapeutic antibodies
dc.subjectTherapeutic drug monitoring
dc.titleEuropean network on optimizing treatment with therapeutic antibodies in Chronic Inflammatory Diseases: Overview, progress and perspectiveseng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.endPage7
oaire.citation.issue6
oaire.citation.startPage1
oaire.citation.titleCTS-Clinical and Translational Science
oaire.citation.volume19
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSantos
person.givenNameMarlene
person.identifier1508370
person.identifier.ciencia-id8311-B967-31C4
person.identifier.orcid0000-0001-5020-5942
person.identifier.scopus-author-id57110502000
relation.isAuthorOfPublication8ce9ee39-a4c6-46ae-99e2-49397b550f1b
relation.isAuthorOfPublication.latestForDiscovery8ce9ee39-a4c6-46ae-99e2-49397b550f1b

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