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Persistent organic pollutant levels in human visceral and subcutaneous adipose tissue in obese individuals - Depot differences and dysmetabolism implications

2014-08Journal article Open access
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dc.contributor.authorPestana, Diogo
dc.contributor.authorFaria, Gil
dc.contributor.authorSá, Carla
dc.contributor.authorFernandes, Virgínia C.
dc.contributor.authorTeixeira, Diana
dc.contributor.authorNorberto, Sónia
dc.contributor.authorFaria, Ana
dc.contributor.authorMeireles, Manuela
dc.contributor.authorMarques, Cláudia
dc.contributor.authorCorreia-Sá, Luísa
dc.contributor.authorCunha, Ana
dc.contributor.authorGuimarães, João T.
dc.contributor.authorTaveira-Gomes, António
dc.contributor.authorSantos, Ana Cristina
dc.contributor.authorDomingues, Valentina F.
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorMonteiro, Rosário
dc.contributor.authorCalhau, Conceição
dc.date.accessioned2015-01-06T15:51:07Z
dc.date.available2015-01-06T15:51:07Z
dc.date.issued2014-08
dc.description.abstractBackground: The role of persistent organic pollutants (POPs) with endocrine disrupting activity in the aetiology of obesity and other metabolic dysfunctions has been recently highlighted. Adipose tissue (AT) is a common site of POPs accumulation where they can induce adverse effects on human health. Objectives: To evaluate the presence of POPs in human visceral (vAT) and subcutaneous (scAT) adipose tissue in a sample of Portuguese obese patients that underwent bariatric surgery, and assess their putative association with metabolic disruption preoperatively, as well as with subsequent body mass index (BMI) reduction. Methods: AT samples (n=189) from obese patients (BMI ≥35) were collected and the levels of 13 POPs were determined by gas chromatography with electron-capture detection (GC-ECD). Anthropometric and biochemical data were collected at the time of surgery. BMI variation was evaluated after 12 months and adipocyte size was measured in AT samples. Results: Our data confirm that POPs are pervasive in this obese population (96.3% of detection on both tissues), their abundance increasing with age (RS=0.310, p<0.01) and duration of obesity (RS=0.170, p<0.05). We observed a difference in AT depot POPs storage capability, with higher levels of ΣPOPs in vAT (213.9±204.2 compared to 155.1±147.4 ng/g of fat, p<0.001), extremely relevant when evaluating their metabolic impact. Furthermore, there was a positive correlation between POP levels and the presence of metabolic syndrome components, namely dysglycaemia and hypertension, and more importantly with cardiovascular risk (RS=0.277, p<0.01), with relevance for vAT (RS=0.315, p<0.01). Finally, we observed an interesting relation of higher POP levels with lower weight loss in older patients. Conclusion: Our sample of obese subjects allowed us to highlight the importance of POPs stored in AT on the development of metabolic dysfunction in a context of obesity, shifting the focus to their metabolic effects and not only for their recognition as environmental obesogens.por
dc.identifier.doi10.1016/j.envres.2014.05.026
dc.identifier.urihttp://hdl.handle.net/10400.22/5317
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.ispartofseriesEnvironmental Research;Vol. 133
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S001393511400187Xpor
dc.subjectAdipose tissuepor
dc.subjectBariatric surgerypor
dc.subjectMetabolic syndromepor
dc.subjectObesitypor
dc.subjectPersistent organicpollutantspor
dc.titlePersistent organic pollutant levels in human visceral and subcutaneous adipose tissue in obese individuals - Depot differences and dysmetabolism implicationspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage177por
oaire.citation.startPage170por
oaire.citation.titleEnvironmental Researchpor
oaire.citation.volume133por
person.familyNameDomingues
person.familyNameDelerue-Matos
person.givenNameValentina Maria Fernandes
person.givenNameCristina
person.identifier.ciencia-id4E16-791D-6664
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0003-3472-849X
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id6603741848
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationbe653ab6-34ec-4329-972a-eee990a7ec66
relation.isAuthorOfPublication09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isAuthorOfPublication.latestForDiscoverybe653ab6-34ec-4329-972a-eee990a7ec66

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