Publication
Patterns of progression of nonproliferative diabetic retinopathy using non-invasive imaging
| dc.contributor.author | Marques, Inês Pereira | |
| dc.contributor.author | Ribeiro, Maria Luísa | |
| dc.contributor.author | Santos, Torcato | |
| dc.contributor.author | Reste-Ferreira, Débora | |
| dc.contributor.author | Mendes, Luís | |
| dc.contributor.author | Martinho, António Cunha-Vaz | |
| dc.contributor.author | Santos, Ana Rita | |
| dc.contributor.author | Figueira, João | |
| dc.contributor.author | Lobo, Conceição | |
| dc.contributor.author | Cunha-Vaz, José | |
| dc.date.accessioned | 2025-06-18T08:41:55Z | |
| dc.date.available | 2025-06-18T08:41:55Z | |
| dc.date.issued | 2024-05 | |
| dc.description.abstract | To identify progression of nonproliferative diabetic retinopathy (NPDR) in patients with type 2 diabetes by combining optical coherence tomography angiography (OCTA) metrics and color fundus photography (CFP) images. This study was a post hoc analysis of a prospective longitudinal cohort study (CORDIS, NCT03696810) with 2-year duration. This study enrolled 122 eyes. Ophthalmological examinations included OCTA and CFP. OCTA metrics included skeletonized vessel density (SVD) and perfusion density (PD) at the superficial capillary plexus (SCP) and deep capillary plexus (DCP). Microaneurysm turnover analysis and Early Treatment Diabetic Retinopathy Study (ETDRS) grading for diabetic retinopathy (DR) severity assessment were performed on 7-field CFP. Eyes graded as ETDRS level 20 showed significant capillary nonperfusion predominantly in the inner ring area in the SCP (P < 0.001), whereas eyes graded as ETDRS level 35 and ETDRS levels 43 and 47 showed significant capillary nonperfusion in both the SCP and DCP in both inner and outer rings (P < 0.001). When evaluating rates of progression in capillary nonperfusion for the 2-year period of follow-up, changes were found predominantly in the DCP for SVD and PD and were better identified in the outer ring area. Microaneurysm turnover contributes to the characterization of NPDR progression by discriminating ETDRS level 35 from ETDRS levels 43 and 47 (P < 0.001), which could not be achieved using only OCTA metrics. Patterns of progression of NPDR can be identified combining OCTA examinations of the superficial and deep retinal capillary plexi of central retina and determination of microaneurysm turnover from fundus photographs. Our study reports results from a registered clinical trial that advances understanding of disease progression in NPDR. | por |
| dc.description.sponsorship | (FITEC)–Programa Interface (FITEC/CIT/2018/2); and Plano de Recuperação e Resiliência (RE-C05-i02)–Missão Interface (03/C05-i02/2022). | |
| dc.identifier.citation | Marques, I. P., Ribeiro, M. L., Santos, T., Reste-Ferreira, D., Mendes, L., Martinho, A. C.-V., Santos, A. R., Figueira, J., Lobo, C., & Cunha-Vaz, J. (2024). Patterns of progression of nonproliferative diabetic retinopathy using non-Invasive imaging. Translational Vision Science & Technology, 13(5), 22. https://doi.org/10.1167/tvst.13.5.22 | |
| dc.identifier.doi | 10.1167/tvst.13.5.22 | |
| dc.identifier.eissn | 2164-2591 | |
| dc.identifier.uri | http://hdl.handle.net/10400.22/30160 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | arvojournals | |
| dc.relation | POCI-01-0145- FEDER-030375 | |
| dc.relation.hasversion | https://tvst.arvojournals.org/article.aspx?articleid=2793688 | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Diabetic retinopathy | |
| dc.subject | Capillary nonperfusion | |
| dc.subject | Optical coherence tomography angiography | |
| dc.subject | Microaneurysms | |
| dc.subject | Diabetes type 2 | |
| dc.title | Patterns of progression of nonproliferative diabetic retinopathy using non-invasive imaging | por |
| dc.type | research article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 9 | |
| oaire.citation.issue | 22 | |
| oaire.citation.startPage | 1 | |
| oaire.citation.title | Translational Vision Science & Technology | |
| oaire.citation.volume | 13 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |