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Anti-inflammatory effect of the antidepressant fluvoxamine – a systematic review

dc.contributor.authorRamalho, A.
dc.contributor.authorCarvalho, R.
dc.contributor.authorBarroso, F.
dc.contributor.authorCruz, A.
dc.contributor.authorSantos, M.
dc.date.accessioned2023-01-19T15:18:36Z
dc.date.available2023-01-19T15:18:36Z
dc.date.issued2022-12-24
dc.description.abstractNeuroinflammation corresponds to the immune response of the nervous system to an injury, infection or neurodegenerative disease characterized by the activation of resident glial cells, including microglia and astrocytes, the release of cytokines and chemokines and the activation and migration of leukocytes. Evidence suggests that inflammatory cytokines may be a central factor, affecting multiple neuronal pathways and contributing to the development of depression. Supporting this neuroinflammatory theory, several studies have demonstrated the anti-inflammatory effect of various antidepressant drugs [1]. Fluvoxamine is a selective serotonin uptake inhibitor (SSRIs) used manly in the treatment of depression and anxiety disorders. Recent evidence pointed that a fluvoxamine early treatment on SARS-CoV-2-infected subjets fully prevented COVID-19 symptoms [2]. Thus, it seems relevant to explore the anti-inflammatory mechanism of fluvoxamine.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRamalho, A., Carvalho, R., Barroso, F., Cruz, A., & Santos, M. (2022). Anti-inflammatory effect of the antidepressant fluvoxamine – a systematic review. Abstracts of the 35th ECNP Congress 2022, 1, 100979. https://doi.org/10.1016/j.nsa.2022.100979pt_PT
dc.identifier.doi10.1016/j.nsa.2022.100979pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/21696
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherECNPpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2772408522009802pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleAnti-inflammatory effect of the antidepressant fluvoxamine – a systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage436pt_PT
oaire.citation.titleNeuroscience Appliedpt_PT
oaire.citation.volumeVolume 1, Supplement 2pt_PT
person.familyNameCruz
person.familyNameSantos
person.givenNameAgostinho
person.givenNameMarlene
person.identifier1508370
person.identifier.ciencia-id8311-B967-31C4
person.identifier.orcid0000-0002-1157-8196
person.identifier.orcid0000-0001-5020-5942
person.identifier.scopus-author-id57110502000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd7ec3c5d-b3e0-4e34-8e24-4d1588876120
relation.isAuthorOfPublication8ce9ee39-a4c6-46ae-99e2-49397b550f1b
relation.isAuthorOfPublication.latestForDiscoveryd7ec3c5d-b3e0-4e34-8e24-4d1588876120

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