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Complexity of the therapeutic regimen in older adults with cancer: associated factors

2024-11-16Artigo de investigação Acesso aberto
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dc.contributor.authorOliveira, Rita F.
dc.contributor.authorOliveira, Ana I.
dc.contributor.authorCruz. Agostinho
dc.contributor.authorRibeiro, Oscar
dc.contributor.authorAfreixo, Vera
dc.contributor.authorPimentel, Francisco
dc.contributor.authorCruz, Agostinho
dc.contributor.authorFerraz Oliveira, Rita
dc.contributor.authorOliveira, Ana Isabel
dc.date.accessioned2026-04-13T09:23:47Z
dc.date.available2026-04-13T09:23:47Z
dc.date.issued2024-11-16
dc.description.abstractPopulation aging is a worldwide phenomenon and is often associated with multimorbidity and polypharmacy. Complex medication regimens are common among older adults and contribute to the occurrence of harmful health outcomes. Age is one of the main risk factors for cancer. This study aimed to determine and characterize the therapeutic complexity in older patients with cancer, and analyze the factors associated with high complexity and the impact of the oncological context. A cross-sectional study with patients aged ≥65 years with cancer was conducted in three hospitals in northern Portugal. Data collection was obtained using self-reports. The medication regimen complexity was assessed using the Medication Regimen Complexity Index (MRCI). Descriptive and association statistical analysis were performed. Logistic, linear, simple and multiple regression analysis were conducted, with and without automatic variable selection. A total of 552 patients were included (median age, 71; IQR, 68–76). The mean MRCI before the oncological context was 18.67 (SD 12.60) and 27.39 (SD 16.67) after the oncological context, presenting a statistically significant difference in the values obtained (p < 0.001). An elevated complexity was significantly associated with polypharmacy, chronic diseases and with the administration of high-risk medications (p < 0.05). High MRCI values showed a relationship with the occurrence of potential drug interactions (p < 0.001). There was no relationship with the existence of cardiac risk comorbidity. This study demonstrated the existence of high therapeutic complexity in older patients with cancer, suggesting the need for intervention to prevent medication-related problems in this vulnerable population.eng
dc.identifier.citationOliveira, R. F., Oliveira, A. I., Cruz, A., Ribeiro, O., Afreixo, V., & Pimentel, F. (2024). Complexity of the Therapeutic Regimen in Older Adults with Cancer: Associated Factors. Pharmaceuticals, 17(11), 1541. https://doi.org/10.3390/ph17111541
dc.identifier.doi10.3390/ph17111541
dc.identifier.eissn1424-8247
dc.identifier.urihttp://hdl.handle.net/10400.22/32206
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationUIDB/04106/2020
dc.relation.hasversionhttps://www.mdpi.com/1424-8247/17/11/1541
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMedication Regimen Complexity Index
dc.subjectMRCI
dc.subjectOlder adults
dc.subjectAging
dc.subjectCancer
dc.subjectPolypharmacy
dc.titleComplexity of the therapeutic regimen in older adults with cancer: associated factorseng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.issue11
oaire.citation.titlePharmaceuticals
oaire.citation.volume17
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCruz
person.familyNameFerraz Oliveira
person.familyNameOliveira
person.givenNameAgostinho
person.givenNameRita
person.givenNameAna Isabel
person.identifier.ciencia-idFD1F-2E0C-1254
person.identifier.orcid0000-0002-1157-8196
person.identifier.orcid0000-0003-3933-5740
person.identifier.orcid0000-0002-3160-6596
relation.isAuthorOfPublicationd7ec3c5d-b3e0-4e34-8e24-4d1588876120
relation.isAuthorOfPublication6c1b7213-1303-47eb-bfa7-ecbef6a9b8d9
relation.isAuthorOfPublicationb38c382c-5355-4b8e-aae0-45af3aa1dc8e
relation.isAuthorOfPublication.latestForDiscoveryd7ec3c5d-b3e0-4e34-8e24-4d1588876120

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