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The impact of metabolic syndrome and type 2 diabetes Mellitus on prostate cancer

2022-03-25Journal article Open access
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dc.contributor.authorSousa, André P.
dc.contributor.authorCosta, Raquel
dc.contributor.authorAlves, Marco G.
dc.contributor.authorSoares, Raquel
dc.contributor.authorBaylina, Pilar
dc.contributor.authorFernandes, Rúben
dc.date.accessioned2024-11-25T11:09:31Z
dc.date.available2024-11-25T11:09:31Z
dc.date.issued2022-03-25
dc.description.abstractProstate cancer (PCa) remains the second most common type of cancer in men worldwide in 2020. Despite its low death rate, the need for new therapies or prevention strategies is critical. The prostate carcinogenesis process is complex and multifactorial. PCa is caused by a variety of mutations and carcinogenic events that constitutes the disease’s multifactorial focus, capable of not only remodeling cellular activity, but also modeling metabolic pathways to allow adaptation to the nutritional requirements of the tumor, creating a propitious microenvironment. Some risk factors have been linked to the development of PCa, including Metabolic Syndrome (MetS) and Type 2 Diabetes Mellitus (T2DM). MetS is intrinsically related to PCa carcinogenic development, increasing its aggressiveness. On the other hand, T2DM has the opposite impact, although in other carcinomas its effect is similar to the MetS. Although these two metabolic disorders may share some developmental processes, such as obesity, insulin resistance, and dyslipidemia, their influence on PCa prognosis appears to have an inverse effect, which makes this a paradox. Understanding the phenomena behind this paradoxical behavior may lead to new concepts into the comprehension of the diseases, as well as to evaluate new therapeutical targets. Thus, this review aimed to evaluate the impact of metabolic disorders in PCa’s aggressiveness state and metabolismpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSousa, A. P., Costa, R., Alves, M. G., Soares, R., Baylina, P., & Fernandes, R. (2022). The impact of metabolic syndrome and type 2 diabetes Mellitus on prostate cancer. Frontiers in Cell and Developmental Biology, 10. https://doi.org/10.3389/fcell.2022.843458pt_PT
dc.identifier.doi10.3389/fcell.2022.843458pt_PT
dc.identifier.eissn2296-634X
dc.identifier.urihttp://hdl.handle.net/10400.22/26456
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationThis work was also supported by FCT - Fundação para a Ciência e Tecnologia (UID/BIM/04293/2013) and by grants NORTE-01-0145- FEDER-000012, SAICT-POL/24325/2016 and FEDER/02/ SAICT/2020/072560.pt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.843458/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMetabolic syndromept_PT
dc.subjectDiabetespt_PT
dc.subjectProstate cancerpt_PT
dc.subjectMetabolismpt_PT
dc.subjectSignaling/signaling pathwayspt_PT
dc.subjectCancer biologypt_PT
dc.titleThe impact of metabolic syndrome and type 2 diabetes Mellitus on prostate cancerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage16pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFrontiers in Cell and Developmental Biologypt_PT
oaire.citation.volume10pt_PT
person.familyNameSousa
person.familyNameBAYLINA MACHADO
person.familyNameFernandes
person.givenNameAndré P.
person.givenNamePILAR
person.givenNameRúben
person.identifier1609329
person.identifier635792
person.identifier.ciencia-id471F-9426-6FFD
person.identifier.ciencia-id1419-F23D-4920
person.identifier.ciencia-id0D1F-4090-E82A
person.identifier.orcid0000-0003-1460-5361
person.identifier.orcid0000-0002-3740-862X
person.identifier.orcid0000-0001-8933-3984
person.identifier.ridB-5134-2010
person.identifier.scopus-author-id56534079700
person.identifier.scopus-author-id57640135700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4f95e9e8-ed83-4437-9236-d742df2d0255
relation.isAuthorOfPublicationb1482a24-d9d8-419d-af68-6df1a75afb3f
relation.isAuthorOfPublication9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4
relation.isAuthorOfPublication.latestForDiscovery9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4

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