Estrogen receptor beta agonist influences presynaptic NMDA receptor distribution in the paraventricular hypothalamic nucleus following hypertension in a mouse model of perimenopause

Sommer, Garrett; López, Claudia Rodríguez; Hirschkorn, Adi; Calimano, Gianna; Marques-Lopes, Jose; Milner, Teresa A.; Glass, Michael J.

http://hdl.handle.net/10400.22/30652

Use this identifier to reference this record.

Name:	Description:	Size:	Format:
ART_José Marques-Lopes.pdf		1.3 MB	Adobe PDF	Download

Send Feedback

Authors

Sommer, Garrett

López, Claudia Rodríguez

Abstract(s)

As women transition to menopause (i.e., perimenopause), they become more susceptible to hypertension. Animal studies using a mouse model of peri-menopause (peri-AOF) have revealed that hypertension susceptibility is associated with increased postsynaptic glutamatergic NMDA receptor plasticity in the paraventricular hypothalamic nucleus (PVN), a brain area critical for blood pressure regulation. The aim of this study was to determine if presynaptic NMDA receptors also play a role in neural plasticity in peri-AOF hypertension susceptibility. For comparison, males were also studied. Following slow pressor Angiotensin II (AngII), both peri-AOF and male mice became hypertensive; however, peri-AOF females showed higher cytoplasmic NMDA receptor levels. To determine the involvement of estrogen signaling in AngII-induced hypertension, an estrogen receptor beta (ERß) agonist was co-administered. In peri-AOF females, but not males, activation of ERß blocked hypertension and increased NMDA receptors on the membrane of axon terminals where it would be more available for binding of glutamate. These results indicate that sex-dependent recruitment of presynaptic NMDA receptors in the PVN is influenced by ERß signaling in a mouse model of perimenopause.

Keywords

Estrogens Estrogen receptor beta Menopause Neural plasticity

URI

http://hdl.handle.net/10400.22/30652

Citation

Sommer, G., Rodríguez López, C., Hirschkorn, A., Calimano, G., Marques-Lopes, J., Milner, T. A., & Glass, M. J. (2024). Estrogen receptor beta agonist influences presynaptic NMDA receptor distribution in the paraventricular hypothalamic nucleus following hypertension in a mouse model of perimenopause. Biology, 13(10), 819. https://doi.org/10.3390/biology13100819