Oxidative Stress Modulation and Radiosensitizing Effect of Quinoxaline-1,4-Dioxides Derivatives

Silva, Liliana; Coelho, Pedro; Teixeira, Dulce; Monteiro, Armanda; Pinto, Gabriela; Soares, Raquel; Prudêncio, Cristina; Vieira, Mónica

http://hdl.handle.net/10400.22/16868

Use this identifier to reference this record.

Name:	Description:	Size:	Format:
ART_Mónica Vieira.pdf		1.34 MB	Adobe PDF	Download

Send Feedback

Authors

Abstract(s)

Quinoxaline-1,4-dioxide (QNX) derivatives are synthetic heterocyclic compounds with multiple biological and pharmacological effects. In this study, we investigated the oxidative status of quinoxaline-1,4-dioxides derivatives in modulating melanoma and glioma cell lines, based on previous results from the research group and their capability to promote cell damage by the production of Reactive Oxygen Species (ROS).

Keywords

Quinoxaline-1 4-dioxides derivatives Oxidative stress Radiation resistance Melanoma Glioma Radiosensitizing

URI

http://hdl.handle.net/10400.22/16868

Citation

Liliana, S., Pedro, C., Dulce, T., Armanda, M., Gabriela, P., Raquel, S., Mónica, V. (2020). Oxidative Stress Modulation and Radiosensitizing Effect of Quinoxaline-1,4-Dioxides Derivatives. Anti-Cancer Agents in Medicinal Chemistry, 20(1), 111-120. doi:http://dx.doi.org/10.2174/1871520619666191028091547