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Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study

2023Journal article Open access
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dc.contributor.authorGuimarães, Juliana
dc.contributor.authorBracchi, Isabella
dc.contributor.authorPinheiro, Cátia
dc.contributor.authorMoreira, Nara Xavier
dc.contributor.authorCoelho, Cláudia Matta
dc.contributor.authorPestana, Diogo
dc.contributor.authorPrucha, Maria do Carmo
dc.contributor.authorMartins, Cristina
dc.contributor.authorDomingues, Valentina F.
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorDias, Cláudia C.
dc.contributor.authorAzevedo, Luís Filipe R.
dc.contributor.authorCalhau, Conceição
dc.contributor.authorLeite, João Costa
dc.contributor.authorRamalho, Carla
dc.contributor.authorKeating, Elisa
dc.contributor.authorFernandes, Virgínia Cruz
dc.date.accessioned2023-03-15T10:40:15Z
dc.date.available2023-03-15T10:40:15Z
dc.date.issued2023
dc.description.abstractThe aims of this study were to characterize the exposure of pregnant women living in Portugal to 3-phenoxybenzoic acid (3-PBA) and to evaluate the association of this exposure with maternal outcomes and newborn anthropometric measures. We also aimed to compare exposure in summer with exposure in winter. Pregnant women attending ultrasound scans from April 2018 to April 2019 at a central hospital in Porto, Portugal, were invited to participate. Inclusion criteria were: gestational week between 10 and 13, confirmed fetal vitality, and a signature of informed consent. 3-PBA was measured in spot urine samples by gas chromatography with mass spectrometry (GC-MS). The median 3-PBA concentration was 0.263 (0.167; 0.458) μg/g creatinine (n = 145). 3-PBA excretion was negatively associated with maternal pre-pregnancy body mass index (BMI) (p = 0.049), and it was higher during the summer when compared to winter (p < 0.001). The frequency of fish or yogurt consumption was associated positively with 3-PBA excretion, particularly during the winter (p = 0.002 and p = 0.015, respectively), when environmental exposure is low. Moreover, 3-PBA was associated with levothyroxine use (p = 0.01), a proxy for hypothyroidism, which could be due to a putative 3-PBA—thyroid hormone antagonistic effect. 3-PBA levels were not associated with the anthropometric measures of the newborn. In conclusion, pregnant women living in Portugal are exposed to 3-PBA, particularly during summer, and this exposure may be associated with maternal clinical features.pt_PT
dc.description.sponsorshipThis article was supported by national funds through the FCT Foundation for Science and Technology, I.P., within the scope of the projects RISE - LA/P/0053/2020; CINTESIS, R&D UNIT (reference UIDB/4255/2020) and LAQV (references: UIDB/50006/2020 AND UIDP/50006/2020). Virgínia Cruz Fernandes was funded by FCT/MCTES (Foundation for Science and Technology and Ministry of Science, Technology and Higher Education) and the ESF (European Social Fund) through NORTE 2020 (North Region Operational Program) through a grant of Post-Doc (reference SFRH/BPD/109153/2015). Juliana Guimarães was funded by FCT/MCTES (Foundation for Science and Technology and Ministry of Science, Technology and Higher Education) under CINTESIS by a PhD scholarship (reference UI/BD/152087/2021). The authors would like to thank the kind participation of all pregnant women and the support of the recruitment activities by the health professionals of the Department of Obstetrics, Centro Hospitalar Universitário S. João, Porto, Portugal and also to the professionals of REQUIMTE/LAQV, Instituto Superior de Engenharia, Politécnico do Porto, for their collaboration in carrying out the analyzes of the 3-PBA metabolite. This work received support from PT national funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the projects LA/P/0053/2020; UIDB/4255/2020; UIDB/5006/2020 and UIDP/50006/2020. Virgínia Cruz Fernandes thanks FCT/MCTES (Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) and ESF (European Social Fund) through NORTE 2020 (Programa Operacional Região Norte) for his/her Post-Doc grant ref. SFRH/BPD/109153/2015). Juliana Guimarães was funded by FCT/MCTES (Foundation for Science and Technology and Ministry of Science, Technology and Higher Education) under CINTESIS by a PhD scholarship (reference UI/BD/152087/2021).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/toxics11020125pt_PT
dc.identifier.issn2305-6304
dc.identifier.urihttp://hdl.handle.net/10400.22/22495
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationRISE-LA/P/0053/2020pt_PT
dc.relationUIDB/4255/2020pt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationFruitec-Modern analytical technologies for assess Persistent and Emergent Organic Pollutants in red fruits
dc.relationEnvironmental pollutants in pregnancy: assessment of exposure and impact in the first 1000 days of life
dc.relation.publisherversionhttps://www.mdpi.com/2305-6304/11/2/125pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subject3-PBApt_PT
dc.subjectPyrethroid pesticidept_PT
dc.subjectPregnancypt_PT
dc.subjectNewbornpt_PT
dc.subjectAnthropometrypt_PT
dc.titleAssociation of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleFruitec-Modern analytical technologies for assess Persistent and Emergent Organic Pollutants in red fruits
oaire.awardTitleEnvironmental pollutants in pregnancy: assessment of exposure and impact in the first 1000 days of life
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBPD%2F109153%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//UI%2FBD%2F152087%2F2021/PT
oaire.citation.issue2pt_PT
oaire.citation.startPage125pt_PT
oaire.citation.titleToxicspt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_NORTE
person.familyNameDomingues
person.familyNameDelerue-Matos
person.familyNameFernandes
person.givenNameValentina Maria Fernandes
person.givenNameCristina
person.givenNameVirgínia
person.identifier.ciencia-id4E16-791D-6664
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.ciencia-id5A16-3713-E0CE
person.identifier.orcid0000-0003-3472-849X
person.identifier.orcid0000-0002-3924-776X
person.identifier.orcid0000-0003-3979-7523
person.identifier.ridD-4990-2013
person.identifier.ridG-4985-2010
person.identifier.scopus-author-id6603741848
person.identifier.scopus-author-id37045954500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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