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Association of trace element status in COVID-19 patients with disease severity

2022-12Journal article Restricted access
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dc.contributor.authorBego, Tamer
dc.contributor.authorMeseldžić, Neven
dc.contributor.authorPrnjavorac, Besim
dc.contributor.authorPrnjavorac, Lejla
dc.contributor.authorMarjanović, Damir
dc.contributor.authorAzevedo, Rui
dc.contributor.authorPinto, Edgar
dc.contributor.authorDuro, Mary
dc.contributor.authorCouto, Cristina
dc.contributor.authorAlmeida, Agostinho
dc.date.accessioned2023-01-17T15:02:11Z
dc.date.available2023-08-04T00:31:06Z
dc.date.issued2022-12
dc.description.abstractCaused by the new SARS-CoV-2 coronavirus, COVID-19 (coronavirus disease 2019) evolves with clinical symptoms that vary widely in severity, from mild symptoms to critical conditions, which can even result in the patient’s death. A critical aspect related to an individual response to SARS-CoV-2 infection is the competence of the immune system, and it is well known that several trace elements are essential for an adequate immune response and have anti-inflammatory and antioxidant properties that are of particular importance in fighting infection. Thus, it is widely accepted that adequate trace element status can reduce the risk of SARS-CoV-2 infection and disease severity. In this study, we evaluated the serum levels of Cu, Zn, Se, Fe, I and Mg in pa- tients (n = 210) with clinical conditions of different severity (“mild”, “moderate”, “severe” and “exitus letalis”, i. e., patients who eventually died). The results showed significant differences between the four groups for Cu, Zn, Se and Fe, in particular a significant trend of Zn and Se serum levels to be decreased and Cu to be increased with the severity of symptoms. For Mg and I, no differences were observed, but I levels were shown to be increased in all groups.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBego, T., Meseldžić, N., Prnjavorac, B., Prnjavorac, L., Marjanović, D., Azevedo, R., Pinto, E., Duro, M., Couto, C., & Almeida, A. (2022). Association of trace element status in COVID-19 patients with disease severity. Journal of Trace Elements in Medicine and Biology, 74, 127055. https://doi.org/https://doi.org/10.1016/j.jtemb.2022.127055pt_PT
dc.identifier.doi10.1016/j.jtemb.2022.127055pt_PT
dc.identifier.issn0946-672X
dc.identifier.urihttp://hdl.handle.net/10400.22/21607
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0946672X22001353?via%3Dihubpt_PT
dc.subjectTrace elementspt_PT
dc.subjectCupt_PT
dc.subjectZnpt_PT
dc.subjectSept_PT
dc.subjectFept_PT
dc.subjectIpt_PT
dc.subjectMgpt_PT
dc.subjectSARS-CoV-2 infectionpt_PT
dc.subjectCOVID-19 severitypt_PT
dc.titleAssociation of trace element status in COVID-19 patients with disease severitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage9pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleJournal of Trace Elements in Medicine and Biologypt_PT
oaire.citation.volume74pt_PT
person.familyNamePinto
person.givenNameEdgar
person.identifier.ciencia-id271F-B7DF-8FAB
person.identifier.orcid0000-0002-8021-4783
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationeaf9fc86-1a1c-437f-adee-d28040aa7f2f
relation.isAuthorOfPublication.latestForDiscoveryeaf9fc86-1a1c-437f-adee-d28040aa7f2f

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