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Biomarkers of NRF2 signalling: Current status and future challenges

2024-03-30Journal article Open access
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dc.contributor.authorMorgenstern, Christina
dc.contributor.authorLastres-Becker, Isabel
dc.contributor.authorDemirdöğen, Birsen Can
dc.contributor.authorCosta, Vera Marisa
dc.contributor.authorDaiber, Andreas
dc.contributor.authorForesti, Roberta
dc.contributor.authorMotterlini, Roberto
dc.contributor.authorKalyoncu, Sibel
dc.contributor.authorArioz, Burak I.
dc.contributor.authorGenc, Sermin
dc.contributor.authorJakubowska, Monika
dc.contributor.authorTrougakos, Ioannis P.
dc.contributor.authorPiechota-Polanczyk, Aleksandra
dc.contributor.authorMickael, Michel
dc.contributor.authorSantos, Marlene
dc.contributor.authorKensler, Thomas W.
dc.contributor.authorCuadrado, Antonio
dc.contributor.authorCopple, Ian M.
dc.date.accessioned2024-04-04T13:43:05Z
dc.date.available2024-04-04T13:43:05Z
dc.date.issued2024-03-30
dc.description.abstractThe cytoprotective transcription factor NRF2 regulates the expression of several hundred genes in mammalian cells and is a promising therapeutic target in a number of diseases associated with oxidative stress and inflammation. Hence, an ability to monitor basal and inducible NRF2 signalling is vital for mechanistic understanding in translational studies. Due to some caveats related to the direct measurement of NRF2 levels, the modulation of NRF2 activity is typically determined by measuring changes in the expression of one or more of its target genes and/or the associated protein products. However, there is a lack of consensus regarding the most relevant set of these genes/proteins that best represents NRF2 activity across cell types and species. We present the findings of a comprehensive literature search that according to stringent criteria identifies GCLC, GCLM, HMOX1, NQO1, SRXN1 and TXNRD1 as a robust panel of markers that are directly regulated by NRF2 in multiple cell and tissue types. We assess the relevance of these markers in clinically accessible biofluids and highlight future challenges in the development and use of NRF2 biomarkers in humans.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationMorgenstern, C., Lastres-Becker, I., Demirdöğen, B. C., Costa, V. M., Daiber, A., Foresti, R., Motterlini, R., Kalyoncu, S., Arioz, B. I., Genc, S., Jakubowska, M., Trougakos, I. P., Piechota-Polanczyk, A., Mickael, M., Santos, M., Kensler, T. W., Cuadrado, A., & Copple, I. M. (2024). Biomarkers of NRF2 signalling: Current status and future challenges. Redox Biology, 103134. https://doi.org/10.1016/j.redox.2024.103134pt_PT
dc.identifier.doi10.1016/j.redox.2024.103134pt_PT
dc.identifier.issn2213-2317
dc.identifier.urihttp://hdl.handle.net/10400.22/25288
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2213231724001101pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectNRF2pt_PT
dc.subjectTranscription factorpt_PT
dc.subjectTarget genespt_PT
dc.subjectBiomarkerpt_PT
dc.subjectOxidative stress responsept_PT
dc.titleBiomarkers of NRF2 signalling: Current status and future challengespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleRedox Biologypt_PT
person.familyNameSantos
person.givenNameMarlene
person.identifier1508370
person.identifier.ciencia-id8311-B967-31C4
person.identifier.orcid0000-0001-5020-5942
person.identifier.scopus-author-id57110502000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8ce9ee39-a4c6-46ae-99e2-49397b550f1b
relation.isAuthorOfPublication.latestForDiscovery8ce9ee39-a4c6-46ae-99e2-49397b550f1b

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