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Impact of umbilical cord mesenchymal stromal/stem cell secretome and cord blood serum in prostate cancer progression

2023-02-19Journal article Restricted access
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dc.contributor.authorSousa, André 
dc.contributor.authorCoelho, Pedro
dc.contributor.authorLeite, Fernanda 
dc.contributor.authorTeixeira, Catarina 
dc.contributor.authorRocha, Ana Catarina 
dc.contributor.authorSantos, Inês 
dc.contributor.authorBaylina, Pilar
dc.contributor.authorFernandes, Ruben 
dc.contributor.authorSoares, Raquel 
dc.contributor.authorCosta, Raquel 
dc.contributor.authorGomes, Andreia 
dc.date.accessioned2023-04-12T15:19:41Z
dc.date.available2023-04-12T15:19:41Z
dc.date.issued2023-02-19
dc.description.abstractProstate cancer (PCa) is the second most common malignancy in men, and the ffth leading cause of death worldwide. Mesenchymal stromal/stem cells (MSC) have been identifed in PCa, although contradictory efects in malignant transformation and tumor progression have been described. Since umbilical cord (UC) MSC and cord blood serum (CBS) are rich in numerous growth and anti-infammatory factors, UC-MSC secretome and CBS are able to modulate tumor cell proliferation and survival as well as immunity and angiogenesis. In the present study, we address this relationship and investigate the infuence of UC-MSC secretome and CBS on two human PCa cell lines (PC3 and LNCaP) and a normal epithelial prostate cell line (HPEpiC). Our results disclosed that upon exposure to UC-MSC-conditioned medium or CBS, both PC3 and LNCaP cells exhibited reduced viability, proliferation, and motility while non-malignant epithelial prostate cells were unafected. These fndings were corroborated by expression analysis of AKT/PI3K signaling pathway, p53 and interleukin genes. UC-MSC and CBS factors decreased the expression of growth-stimulating AKT and PI3K efectors and simultaneously up-regulated the expression of tumor-suppressor p53. Moreover, a more anti-infammatory expression profle was found in both malignant PCa cell lines. Altogether, these results shed light into possible mechanisms by which UC-MSC and CBS reduce PCa progression, further reinforcing their potential use as novel therapeutic agents in PCa.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSousa, A., Coelho, P., Leite, F. et al. Impact of umbilical cord mesenchymal stromal/stem cell secretome and cord blood serum in prostate cancer progression. Human Cell (2023). https://doi.org/10.1007/s13577-023-00880-zpt_PT
dc.identifier.doi10.1007/s13577-023-00880-zpt_PT
dc.identifier.eissn1749-0774
dc.identifier.issn0914-7470
dc.identifier.urihttp://hdl.handle.net/10400.22/22718
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s13577-023-00880-zpt_PT
dc.subjectUmbilical cordpt_PT
dc.subjectMesenchymal stem/stromal cellspt_PT
dc.subjectProstate cancerpt_PT
dc.subjectCord blood serumpt_PT
dc.subjectAcellular therapypt_PT
dc.titleImpact of umbilical cord mesenchymal stromal/stem cell secretome and cord blood serum in prostate cancer progressionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage13pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleHuman Cellpt_PT
person.familyNameCoelho
person.familyNameBAYLINA MACHADO
person.givenNamePedro
person.givenNamePILAR
person.identifier.ciencia-idBE18-3DB2-8D79
person.identifier.ciencia-id1419-F23D-4920
person.identifier.orcid0000-0002-2343-1108
person.identifier.orcid0000-0002-3740-862X
person.identifier.ridAAZ-9239-2020
person.identifier.ridB-5134-2010
person.identifier.scopus-author-id57214054449
person.identifier.scopus-author-id56534079700
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationeb030614-4140-437b-8ac3-f59c52566ecf
relation.isAuthorOfPublicationb1482a24-d9d8-419d-af68-6df1a75afb3f
relation.isAuthorOfPublication.latestForDiscoveryb1482a24-d9d8-419d-af68-6df1a75afb3f

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