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Abstract(s)
Sulfadiazine is an antibiotic of the sulfonamide
group and is used as a veterinary drug in fish farming.
Monitoring it in the tanks is fundamental to control the
applied doses and avoid environmental dissemination.
Pursuing this goal, we included a novel potentiometric
design in a flow-injection assembly. The electrode body
was a stainless steel needle veterinary syringe of 0.8-mm
inner diameter. A selective membrane of PVC acted as a
sensory surface. Its composition, the length of the electrode,
and other flow variables were optimized. The best
performance was obtained for sensors of 1.5-cm length
and a membrane composition of 33% PVC, 66% onitrophenyloctyl
ether, 1% ion exchanger, and a small
amount of a cationic additive. It exhibited Nernstian slopes
of 61.0 mV decade-1 down to 1.0×10-5 mol L-1, with a limit
of detection of 3.1×10-6 mol L-1 in flowing media. All
necessary pH/ionic strength adjustments were performed
online by merging the sample plug with a buffer carrier of
4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, pH
4.9. The sensor exhibited the advantages of a fast response
time (less than 15 s), long operational lifetime (60 days),
and good selectivity for chloride, nitrite, acetate, tartrate,
citrate, and ascorbate. The flow setup was successfully
applied to the analysis of aquaculture waters. The analytical
results were validated against those obtained with liquid
chromatography–tandem mass spectrometry procedures.
The sampling rate was about 84 samples per hour and
recoveries ranged from 95.9 to 106.9%.
Description
Keywords
Sulfadiazine Chemical sensor. Aquaculture Flow-injection analysis Potentiometry
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Original Paper