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Unraveling the nutraceutical potential of Salicornia ramosissima by-product – impact of gastrointestinal digestion and intestinal permeability on in vitro bioactivity

2025-09-15Research article Embargoed access
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dc.contributor.authorPinto, Diana
dc.contributor.authorSantos, Inês
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorTeixeira, Filipa
dc.contributor.authorSut, Stefania
dc.contributor.authorDall’Acqua, Stefano
dc.contributor.authorVieira, Mónica
dc.contributor.authorRodrigues, Francisca
dc.contributor.authorAlmeida Vieira, Mónica Andreia
dc.date.accessioned2025-11-21T16:38:50Z
dc.date.available2025-11-21T16:38:50Z
dc.date.issued2025-09-15
dc.description.abstractSalicornia ramosissima by-product (SP) is an underexploited antioxidant-rich by-product. This study explored the phytochemical profile, bioaccessibility, and biological activity of SP before and after extraction (SBE and SAE, respectively) upon gastrointestinal simulated digestion and intestinal permeability. The phenolic and flavonoid concentrations increased during digestion, reaching bioaccessibility rates above 95 % for both SBE and SAE. Promising antioxidant/antiradical properties and neuroprotective effects were attested upon digestion. Regarding the phytochemical profile, 17 compounds were identified, including (di)caffeoylquinic acids, gallocatechin, and triterpenoid saponins. The intestinal absorption of bioactive compounds from SAE and SBE intestinal digests was proven through a Caco-2/HT29-MTX cells co-culture model, with 4-caffeoylquinic acid (34.84 %) and 4,5-dicaffeoylquinic acid (26.73 %) reaching the highest permeation rates after 4 h, respectively, for SAE and SBE. These findings support the harnessing of SP as a promising functional and nutraceutical ingredient rich in pro-healthy compounds with proven bioactivity upon in vitro digestion and intestinal permeation.por
dc.identifier.citationPinto, D., Santos, I., Teixeira, F., Sut, S., Vieira, M., Salazar, M., Delerue-Matos, C., Dall’Acqua, S., & Rodrigues, F. (2025). Unraveling the nutraceutical potential of Salicornia ramosissima by-product – impact of gastrointestinal digestion and intestinal permeability on in vitro bioactivity. Food Chemistry, 486, 144665. https://doi.org/10.1016/j.foodchem.2025.144665
dc.identifier.doi10.1016/j.foodchem.2025.144665
dc.identifier.eissn1873-7072
dc.identifier.issn0308-8146
dc.identifier.urihttp://hdl.handle.net/10400.22/31034
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationUID/50006
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0308814625019168?via%3Dihub
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectGlasswort
dc.subjectPhytochemicals
dc.subjectInfogest protocol
dc.subjectIntestinal model
dc.subjectRadicals scavenging
dc.titleUnraveling the nutraceutical potential of Salicornia ramosissima by-product – impact of gastrointestinal digestion and intestinal permeability on in vitro bioactivitypor
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.titleFood Chemistry
oaire.citation.volume486
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameAlmeida Vieira
person.givenNameMónica Andreia
person.identifier.ciencia-idA01E-9178-9B48
person.identifier.orcid0000-0002-8687-4811
relation.isAuthorOfPublication861e9c68-4ecc-4be1-a794-852343368e9a
relation.isAuthorOfPublication.latestForDiscovery861e9c68-4ecc-4be1-a794-852343368e9a

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