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  • Is endometriosis staging related to the type and intensity of patients’ complaints? A systematic review and meta-analysis
    Publication . Alves, João Sequeira; Meneses, Tânia; Mariano, Mafalda; Serra, Sofia Silvério; Costa, Teresa; Martins, João Paulo; Rabishong, Benoit; Lima, Jorge; Oliveira Martins, João Paulo
    To evaluate the association between the endometriosis staging and the type and intensity of pain reported by patients, describing the pain intensity across different pain types. On January 27, 2025, a systematic search was conducted in PubMed, Scopus, Web of Science, EMBASE, and the Cochrane Library. The search terms included endometriosis, pain, dysmenorrhea, dyspareunia, pelvic pain, dyschezia, dysuria, and classification. Eligible studies examined women with endometriosis, assessing how endometriosis staging (rASRM or ENZIAN classification) correlated with pain symptoms (dysmenorrhea, dyspareunia, dyschezia, dysuria, and chronic pelvic pain) measured with validated tools. Two reviewers extracted data independently, with a third verifying results. Pain scores were log-transformed to stabilize variance, and proportions of women with advanced endometriosis were analyzed on the logit scale. Given high heterogeneity, random-effects models with restricted maximum likelihood were used. Of 2527 records, 112 studies were reviewed and eight met inclusion criteria (seven using rASRM, one using ENZIAN). Dysmenorrhea showed the highest mean intensity (6.61, 95% CI: 4.43–10.10), while dysuria was lowest (1.08, 95% CI: 0.62–1.89). Pain intensity did not differ significantly between rASRM stages I/II and III/IV (p > 0.05), though chronic pelvic pain was more frequent in advanced disease (p < 0.05). Dysmenorrhea is linked to higher pain intensity in women with endometriosis, while dysuria is linked to lower intensity. Pain intensity is not associated with the rASRM stage; however, chronic pelvic pain seems more prevalent in advanced stages of the disease.
    2025-12-01Artigo científico Acesso embargado Ver mais
  • Ultrafine Ru on Reduced Graphene Oxide-La2O3 Binary Support for Highly Efficient Hydrogen Evolution Reaction
    Publication . Jiaying Zhang; Qijing Zhang; Jingyi Qiu; Xiaoying Zhang; Zhiyuan Zhu; Hongyan Chen; Konggang Qu; Lijian Meng
    Ru-based catalysts are recognized as one of the most competitive candidates for hydrogen evolution reaction (HER). Nonetheless, reducing Ru loading and maximizing atomic utilization remain paramount priorities for achieving optimal cost efficiency. Herein, the ultrafine Ru nanoparticles loaded on a reduced graphene oxide- La2O3 binary support (Ru/La2O3-rGO) was rationally designed via a simple liquid impregnation method with a low-content Ru of 6.1 wt%. Benefitting from the synergistic interplay of the binary substrate, Ru/La2O3-rGO achieves a current density of 10 mA cm􀀀 2 at an ultrasmall overpotential of 15.8 mV for alkaline HER, outperforming Pt/C, while also exhibiting good stability and high intrinsic activity. This work offers novel insights into the rational design of high-performance, stable, and cost-effective Ru-based HER catalysts.
    2025-12-01Texto Acesso aberto Ver mais