Percorrer por data de Publicação, começado por "2025-08-14"
A mostrar 1 - 2 de 2
Resultados por página
Opções de ordenação
- Immunogenicity as a predictor of Influenza vaccine efficacy: A systematic reviewPublication . Martins, André Miguel; Juan, Luis Félix Valero; Santos, Marlene; Martins, João Paulo; Santos, Marlene; Oliveira Martins, João PauloInfluenza represents a significant burden on global public health, and vaccination is the most effective strategy to reduce it. The large investment in vaccination programs and the need for adjustments in vaccine serotypes are important reasons for evaluating the influenza vaccine’s efficacy every year. Establishing a relationship between immunogenicity data and efficacy is also crucial for predicting the efficacy of a vaccine during its development. Antibody response measurement is one of the most common methods for evaluating immunogenicity, particularly in vaccines and biologics. The aim of this systematic review was to define a model that relates the immunogenicity of a given vaccine to its efficacy, based on hemagglutination inhibition titer levels. To achieve this goal, information was gathered from articles linking immunogenicity with the efficacy of the influenza vaccine in the Medline and Scopus databases. Different mathematical models were developed and applied to assess the relationship between HAI titers and the effectiveness of the flu vaccine. This analysis was conducted for the various existing vaccines, for the different influenza virus strains, and for their efficacy in paediatric populations. The r2 obtained ranged from 0.2579 to 0.966, which points to the importance of this immunological factor in the efficacy of the influenza vaccine. Conclusions: The efficacy values for titer level 40 confirm the validity of the data provided by Hobson.
- Confined RuP2 Nanoparticles in N,P,S-tridoped Carbon as Superior Electrocatalyst for pH-Wide Hydrogen EvolutionPublication . Yu Sun, Haibo Li, Suyuan Zeng, Rui Li, Qingxia Yao, Hongyan Chen, Yinghua Wang, Konggang Qu, Lijian MengHydrogen has been deemed as the ideal energy source and carrier due to its unmatched energy efficiency and sustainability. Nevertheless, there is a pressing need to develop cost-effective materials to replace costly Pt in the hydrogen evolution reaction (HER), and the electrocatalysts with low overpotential and robust stability under various conditions is a particularly significant concern. In this study, a straightforward and effective approach was proposed for the precise synthesis of RuP2 nanoparticles encapsulated in N, P, S-tridoped carbon, which involves utilizing zinc pyrithione, phytic acid and Ru salt as starting materials. The effect of different Ru loadings on the morphology and structures of the composite catalysts was examined carefully. The obtained composites exhibit superior alkaline activity surpassing commercial Pt/C and comparable acidic and neutral activity as well as excellent pH-wide stability. DFT computations reveal the integration of RuP2 with tridoped carbon can tailor the electronic structure of Ru active sites by interfacial electron transfer, thus optimizing the adsorption energy and promoting the HER activity. The benign graphitization of doped carbon and porous structures ensure the smooth charge and mass transfer during HER process. The cost-effective and straightforward synthesis methods presented in this work offer a promising alternative to commercial Pt/C for practical hydrogen-related applications.