Browsing by Issue Date, starting with "2025-06-12"
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- Influence of puncture devices on the accuracy of cyclophosphamide dosing for chemotherapy administrationPublication . Carvalho, Susana; Cardoso, Andreia; Ferreira, Débora; Silva, Diana Dias da; Moreira, Fernando; Moreira, Fernando; Dias da Silva, Diana CristinaCyclophosphamide is one of the most commonly used cytotoxic drugs in chemotherapy protocols. Its preparation in the hospital setting involves handling concentrated solutions, which pose occupational exposure risks and potential variations in the final dose administered. The aim of this study was to evaluate the effect of aspiration devices on the concentration of cyclophosphamide in reconstituted solutions. An analytical method was validated using high-performance liquid chromatography coupled to a diode-array detector (HPLC-DAD) for quality control. Cyclophosphamide solutions were prepared and aspirated using either a conventional needle or spike device with or without a filtration system. The validated method demonstrated linearity (R2 = 0.9999), high precision (0.22–4.59%) and accuracy (88.9–99.4%), with a limit of quantification of 4.03 µg/mL. Significant differences (p < 0.001) were observed between samples aspirated with a needle and those aspirated with a spike fitted with a 5 µm filter, with the latter showing lower cyclophosphamide concentrations, suggesting partial retention of the drug. No significant differences were found between the needle and filterless spike preparations. These results suggest that the choice of aspiration device influences the final drug concentration, potentially affecting therapeutic efficacy. Standardisation of preparation techniques and an awareness of device limitations are essential to ensure accurate chemotherapy dosing and patient safety.
- EEG signatures during pregnancy and their role on parenting-related measures: scoping reviewPublication . Braga, Patrícia Vilela; Amaoui, Sofia; Lamela, Diogo; Jongenelen, Inês; Costa, Raquel; Oliveira, Jorge; Pasion, Rita; Pinto, Tiago Miguel; Paiva, Tiago Oliveira; Campos, Carlos; Campos, CarlosThis scoping review aims to map and synthesise the current research evidence targeting the electroencephalography (EEG) neural correlates during pregnancy and its association with parenting-related measures during pregnancy and postpartum period. Pregnancy is characterised by a wide range of biological changes associated with adaptation to parenthood. A growing body of literature has examined the neural correlates of pregnancy using EEG, revealing distinct patterns in pregnant females, with these EEG metrics changing throughout gestation and postpartum. Due to the heterogeneity of the evidence, the current literature lacks an organised synthesis, making it difficult to understand the neural correlates during pregnancy and their association with parentingrelated measures during pregnancy and postpartum period. Studies will be included if they contain a quantitative EEG metric in their assessment in pregnant women. Studies will be included if they involve clinical or community samples. No sociodemographic, obstetric, or health exclusion criteria will be applied. The scoping review will be conducted following the Joanna Briggs Institute’s (JBI) guidelines and will be reported following Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. Searches will be conducted in 7 databases (Cochrane for Trials and Reviews, PsycInfo, PubMed, Psychological and Behavioural Science Collection, Scopus and Web of Science Core Collection) for articles published in English, Portuguese, or Spanish with no limitation on the region or publication time frame. Two independent reviewers will screen each record following a standardised flowchart using asreview lab. Data extraction will be performed by the two reviewers using charting tables in Excel. Disagreements at any step will be resolved via consensus or by a third reviewer. Results will be reported using tables and graphs along with a descriptive analysis, according to the research questions.