Browsing by Issue Date, starting with "2023-08-02"
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- DNA methylation as a triage marker for colposcopy referral in HPV-based cervical cancer screening: a systematic review and meta-analysisPublication . Salta, Sofia; Lobo, João; Magalhães, Bruno; Henrique, Rui; Jerónimo, CarmenScreening plays a key role in secondary prevention of cervical cancer. High-risk human papillomavirus (hrHPV) testing, a highly sensitive test but with limited specificity, has become the gold standard frontline for screening programs. Thus, the importance of effective triage strategies, including DNA methylation markers, has been emphasized. Despite the potential reported in individual studies, methylation markers still require validation before being recommended for clinical practice. This systematic review and meta-analysis aimed to evaluate the performance of DNA methylation-based biomarkers for detecting high-grade intraepithelial lesions (HSIL) in hrHPV-positive women. Hence, PubMed, Scopus, and Cochrane databases were searched for studies that assessed methylation in hrHPV-positive women in cervical scrapes. Histologically confirmed HSIL was used as endpoint and QUADAS-2 tool enabled assessment of study quality. A bivariate random-effect model was employed to pool the estimated sensitivity and specificity as well as positive (PPV) and negative (NPV) predictive values. Twenty-three studies were included in this meta-analysis, from which cohort and referral population-based studies corresponded to nearly 65%. Most of the women analyzed were Dutch, and CADM1, FAM19A4, MAL, and miR124-2 were the most studied genes. Pooled sensitivity and specificity were 0.68 (CI 95% 0.63–0.72) and 0.75 (CI 95% 0.71–0.80) for cervical intraepithelial neoplasia (CIN) 2+ detection, respectively. For CIN3+ detection, pooled sensitivity and specificity were 0.78 (CI 95% 0.74–0.82) and 0.74 (CI 95% 0.69–0.78), respectively. For pooled prevalence, PPV for CIN2+ and CIN3+ detection were 0.514 and 0.392, respectively. Furthermore, NPV for CIN2+ and CIN3+ detection were 0.857 and 0.938, respectively. This meta-analysis confirmed the great potential of DNA methylation-based biomarkers as triage tool for hrHPV-positive women in cervical cancer screening. Standardization and improved validation are, however, required. Nevertheless, these markers might represent an excellent alternative to cytology and genotyping for colposcopy referral of hrHPV-positive women, allowing for more cost-effective screening programs.
- Towards Ubiquitous Semantic Metaverse: Challenges, Approaches, and OpportunitiesPublication . Li, Kai; Lau, Billy Pik Lik; Yuan, Xin; Ni, Wei; Guizani, Mohsen; Yuen, ChauIn recent years, ubiquitous semantic Metaverse has been studied to revolutionize immersive cyber-virtual experiences for augmented reality (AR) and virtual reality (VR) users, which leverages advanced semantic understanding and representation to enable seamless, context-aware interactions within mixed-reality environments. This survey focuses on the intelligence and spatio-temporal characteristics of four fundamental system components in ubiquitous semantic Metaverse, i.e., artificial intelligence (AI), spatio-temporal data representation (STDR), semantic Internet of Things (SIoT), and semantic-enhanced digital twin (SDT). We thoroughly survey the representative techniques of the four fundamental system components that enable intelligent, personalized, and context-aware interactions with typical use cases of the ubiquitous semantic Metaverse, such as remote education, work and collaboration, entertainment and socialization, healthcare, and e-commerce marketing. Furthermore, we outline the opportunities for constructing the future ubiquitous semantic Metaverse, including scalability and interoperability, privacy and security, performance measurement and standardization, as well as ethical considerations and responsible AI. Addressing those challenges is important for creating a robust, secure, and ethically sound system environment that offers engaging immersive experiences for the users and AR/VR applications.