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  • Determinism of Replicated Distributed Systems–A Timing Analysis of the Data Passing Process
    Publication . Santos, Adriano A; Silva, A. Ferreira da; Magalhães, António; Sousa, Mário de
    Fault-tolerant applications are created by replicating the software or hardware component in a distributed system. Communications are normally carried out over an Ethernet network to interact with the distributed/replicated system, ensuring atomic multicast properties. However, there are situations in which it is not possible to guarantee that the replicas process the same data set in the same order. This occurrence will lead to inconsistency in the data set produced by the replicas, that is, the determinism of the applications is not guaranteed. To avoid these inconsistencies, a set of Function Blocks has been proposed which, taking advantage of the inherent properties of Ethernet, can guarantee the synchronism and determinism of the real-time application. This paper presents this set of Function Blocks, focusing our action on the development of reliable distributed systems in real-time. This demonstrates that the developed Function Blocks can guarantee the determinism of the replicas and, as such, that the messages sent are processed, in the same order and according to the time in which they were made available.
    2020-11-20Journal article Open access Show more
  • 4,9-Diaminoacridines and 4-Aminoacridines as Dual-Stage Antiplasmodial Hits
    Publication . Fonte, Mélanie; Tassi, Natália; Fontinha, Diana; Bóuzon-Arnáiz, Inês; Ferraz, Ricardo; Araújo, Maria J.; Fèrnandez-Busquets, Xavier; Prudêncio, Miguel; Gomes, Paula; Teixeira, Cátia
    Multi‐stage drugs have been prioritized in antimalarial drug discovery, as targeting more than one process in the Plasmodium life cycle is likely to increase efficiency, while decreasing the chances of emergence of resistance by the parasite. Herein, we disclose two novel acridine‐based families of compounds that combine the structural features of primaquine and chloroquine. Compounds prepared and studied thus far retained the in vitro activity displayed by the parent drugs against the erythrocytic stages of chloroquine‐sensitive and ‐resistant Plasmodium falciparum strains, and against the hepatic stages of Plasmodium berghei, hence acting as dual‐stage antiplasmodial hits.
    2020-11-20Journal article Open access Show more