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Browsing by Issue Date, starting with "2014-11-01"

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  • A edificação da violinística moderna na encruzilhada para o século XX
    Publication . Siegle, Mário Leonardo; Ungureanu, Radu Benone
    Esta dissertação serve o propósito de expor o que foi considerado como violinística moderna, surgida no início do Séc. XX, mas perpetuada até aos nossos dias; a referência fundamental para este trâmite será o livro "Seis sonatas para Violino Solo" de Eugène Ysaÿe. Este livro foi dedicado a seis violinistas, que, apesar de terem todos estilos e técnicas diferentes, criaram no conjunto uma nova aborgadem à prática do violino, que é utilizada até hoje. São estes (por ordem das sonatas dedicadas): Joseph Szigeti, Jacques Thibaud, Georges Enesco, Fritz Kreisler, Mathieu Crickboom e Manuel Quiroga. Para conseguir expor essa edificação, Foram analisadas as características de cada um, bem como a relação entre os mesmos, para descobrir e entender as inovações implementadas. Foram utilizados diferentes métodos de investigação, com várias abordagens para cada um. Assim, a pesquisa será particular em cada caso, pois depende não só da relevância que o violinista teve, mas também do legado que deixou. De um modo geral tratar-se-á de analisar: obras compostas pelos autores (que darão uma muito valiosa perspectiva do seu pensamento violinístico específico e da sua capacidade de inovação), gravações dos mesmos (sendo um excelente meio de análise das suas interpretações), livros editados (dos próprios ou de outros) que falem de algum dos sete violinistas em foco, teses/artigos/documentários ou outros vários sobre estes.
    2014-11-01Master thesis Open access Show more
  • Electrochemical immunosensor for the analysis of the breast cancer biomarker HER2 ECD
    Publication . Marques, Raquel Cristina Barroso; Viswanathan, Subramanian; Nouws, Henri P. A.; Delerue-Matos, Cristina; González-García, Maria Begoña
    Human epidermal growth factor receptor 2 (HER2) is a breast cancer biomarker that plays a major role in promoting breast cancer cell proliferation and malignant growth. The extracellular domain (ECD) of HER2 can be shed into the blood stream and its concentration is measurable in the serum fraction of blood. In this work an electrochemical immunosensor for the analysis of HER2 ECD in human serum samples was developed. To achieve this goal a screen-printed carbon electrode, modified with gold nanoparticles, was used as transducer surface. A sandwich immunoassay, using two monoclonal antibodies, was employed and the detection of the antibody–antigen interaction was performed through the analysis of an enzymatic reaction product by linear sweep voltammetry. Using the optimized experimental conditions the calibration curve (ip vs. log[HER2 ECD]) was established between 15 and 100 ng/mL and a limit of detection (LOD) of 4.4 ng/mL was achieved. These results indicate that the developed immunosensor could be a promising tool in breast cancer diagnostics, patient follow-up and monitoring of metastatic breast cancer since it allows quantification in a useful concentration range and has an LOD below the established cut-off value (15 ng/mL).
    2014-11-01Journal article Open access Show more
  • Fresh-cut aromatic herbs: Nutritional quality stability during shelf-life
    Publication . Santos, J.; Herrero, M.; Mendiola, J. A.; Oliva-Teles, M. T.; Ibáñez, E.; Delerue-Matos, Cristina; Oliveira, M. Beatriz P. P.
    Fresh-cut vegetables are a successful convenient healthy food. Nowadays, the presence of new varieties of minimally processed vegetables in the market is common in response to the consumers demand for new flavours and high quality products. Within the most recent fresh-cut products are the aromatic herbs. In this work, the objective was to evaluate the nutritional quality and stability of four fresh-cut aromatic herbs. Several physicochemical quality characteristics (colour, pH, total soluble solids, and total titratable acidity) were monitored in fresh-cut chives, coriander, spearmint and parsley leaves, stored under refrigeration (3 ± 1 ºC) during 10 days. Their nutritional composition was determined, including mineral composition (phosphorous, potassium, sodium, calcium, magnesium, iron, zinc, manganese and copper) and fat- and water-soluble vitamin contents. Total soluble phenolics, flavonoids and the antioxidant capacity were determined by spectrophotometric methods. The aromatic herbs kept their fresh appearance during the storage, maintaining their colour throughout shelf-life. Their macronutrient composition and mineral content were stable during storage. Coriander had the highest mineral and fatsoluble vitamin content, while spearmint showed the best scores in the phenolic, flavonoid and antioxidant capacity assays. Vitamins and antioxidant capacity showed some variation during storage, with a differential behaviour of each compound according to the sample.
    2014-11-01Journal article Restricted access Show more