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  • The effect of antihistamines on the cardiovascular system: a systematic review
    Publication . Soares, Mariana; Oliveira, Ana Isabel; Oliveira, Rita F.; Oliveira, Ana Isabel; Ferraz Oliveira, Rita
    Antihistamines are widely used for allergic diseases but have been associated with adverse cardiovascular effects. Once considered rare, these effects have gained clinical relevance due to population ageing, polypharmacy, and comorbidities [1]. Despite case reports and narrative reviews, recent systematic reviews are lacking. To critically assess current evidence on the cardiovascular effects of antihistamines. A systematic literature review was conducted using PubMed and ScienceDirect, following PRISMA guidelines. Studies published from January 2013 to May 2025 were considered. Of 99 records identified, 18 duplicates were removed, 75 were excluded by title and abstract, and one after full-text review. Five studies were included. Designs varied (case reports, cohort studies, clinical trials, experimental research), and methodological quality was assessed using Joanna Briggs Institute checklists, selected for their adaptability to multiple study types. Both adult and paediatric populations were included. The findings suggest a possible link between first-generation H1 antihistamines and increased risk of arrhythmias and ischaemic cardiac events, particularly in children. Some studies also noted potential therapeutic benefits in specific contexts, such as long COVID. Overall, evidence remains limited by methodological heterogeneity and small sample sizes. The results support caution in prescribing antihistamines, especially in vulnerable populations, and reinforce the need for further robust studies to better define their cardiovascular safety.
    2025-10Documento de conferência Acesso aberto Ver mais