Browsing by Author "Silva, Patrícia"
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- Discovery of a New Xanthone against Glioma: Synthesis and Development of (Pro)liposome FormulationsPublication . Alves, Ana; Correia-da-Silva, Marta; Nunes, Claúdia; Campos, João; Sousa, Emília; Silva, Patrícia; Bousbaa, Hassan; Rodrigues, Francisca; Ferreira, Domingos; Costa, Paulo; Pinto, MadalenaFollowing our previous work on the antitumor activity of acetylated flavonosides, a new acetylated xanthonoside, 3,6-bis(2,3,4,6-tetra-O-acetyl-β-glucopyranosyl)xanthone (2), was synthesized and discovered as a potent inhibitor of tumor cell growth. The synthesis involved the glycosylation of 3,6-di-hydroxyxanthone (1) with acetobromo-α-d-glucose. Glycosylation with silver carbonate decreased the amount of glucose donor needed, comparative to the biphasic glycosylation. Xanthone 2 showed a potent anti-growth activity, with GI50 < 1 μM, in human cell lines of breast, lung, and glioblastoma cancers. Current treatment for invasive brain glioma is still inadequate and new agents against glioblastoma with high brain permeability are urgently needed. To overcome these issues, xanthone 2 was encapsulated in a liposome. To increase the well-known low stability of these drug carriers, a proliposome formulation was developed using the spray drying method. Both formulations were characterized and compared regarding three months stability and in vitro anti-growth activity. While the proliposome formulation showed significantly higher stability, it was at the expense of losing its biocompatibility as a drug carrier in higher concentrations. More importantly, the new xanthone 2 was still able to inhibit the growth of glioblastoma cells after liposome formulation.
- Efeito da eletrolipólise no tecido adiposo abdominal: estudo pilotoPublication . Couto, Miriam; Noites, Andreia; Silva, Patrícia; Adubeiro, NunoO excesso de tecido adiposo abdominal associa-se a distúrbios cardiometabólicos. A microcorrente associada ao exercício físico aeróbio poderá auxiliar na estimulação da lipólise para diminuir a quantidade dessa gordura.
- A influência da electrolipólise associada ao exercício físico na atividade metabólicaPublication . Noites, Andreia; Couto, Miriam Faria; Monteiro, Pedro; Vieira, Ágata; Adubeiro, Nuno; Carvalho, Paulo; Gouveia, Ana; Nunes, Ana; Mota, Alexandra; Leal, Carla; Rodrigues, Cláudia; Sousa, Gisela; Silva, PatríciaO excesso de gordura abdominal associa-se a patologias cardiometabólicas. A microcorrente poderá ser coadjuvante ao exercício aeróbio na estimulação da lipólise, prevenindo riscos de saúde. O exercício físico aeróbio constitui uma modalidade capaz de diminuir o tecido adiposo, por estimular a lipólise através da elevação do nível de catecolaminas, resultantes do aumento da actividade do sistema nervoso simpático. O tipo de exercício físico mais adequado para consumo predominante de lípidos é o exercício aeróbio prolongado e de intensidade moderada. No entanto, na prática de exercício físico as fontes lipídicas são globais o que sustenta a utilidade de procedimentos que promovam o gasto de gordura localizada na região abdominal. A electrolipólise, que pode ser realizada pela aplicação de microcorrente de baixa frequência, poderá ser usada com este intuito, uma vez que a activação do sistema nervoso simpático, juntamente com a alteração da polaridade da membrana celular dos adipócitos e o aumento do fluxo sanguíneo, parecem ser os responsáveis pela promoção da lipólise e aumento do metabolismo local. Para além destes mecanismos, a microcorrente favorece a degradação de triglicerídeos ao promover a activação das enzimas triglicerídeo lípase e lípase hormono-sensível. Após a hidrólise de triglicerídeos torna-se fulcral o exercício físico para que os ácidos gordos em circulação sejam utilizados como fonte de energia. Porém não existe evidência científica que comprove os efeitos da electrolipólise associada ao exercício físico bem como consenso nos parâmetros que devem ser utilizados para electrolipólise, neste sentido vários estudos tem sido realizados no âmbito da linha de investigação de sistema tegumentar e metabólico da ESTSP.
- m-Health system for the self-management of patients with heart failurePublication . Silva, Patrícia; Gomes, Paulo Veloso; Condeço, Jorge; Marques, António; Curado, Henrique; Veloso, Rita; Pereira, JavierIncreasingly, the use of technology is emerging as a tool to support health care. The new information and telecommunications technologies have triggered a new paradigm in health: in access, availability and management of information. Telemonitoring interventions in patients with heart failure have been shown to be cost effective in reducing the rate of hospitalisations and mortality. The development of m-Health applications focused on the centralization of care in patients, considering the perspectives of different stakeholders, promises results not only in clinical (mortality and morbidity) but also in patient outcome reports (quality of life and self-care). This work presents an integrated information system for telemonitoring and self-management of patients with heart failure.
- Telemonitoring in heart failure patient managementPublication . Silva, Patrícia; Gomes, Paulo Veloso; Condeço, Jorge; Curado, Henrique; Veloso, RitaHeart failure is a highly prevalent clinical syndrome, associated with high costs to the national health system and with a negative impact on patients’ quality of life. In order to reduce mortality, the rate of hospitalisations and improve quality of life, the empowerment of the patient for self-care from self-monitoring of signs and symptoms, taking medication, education about the disease, is a pillar of the treatment so that they can recognise signs of exacerbation of the disease in time and resort to health services early. Mobile health apps (mHealthh) have shown promise as a tool to engage and promote patient self-care, decreasing mortality and hospitalisations. However, to improve outcomes, more robust studies are needed on the development of the applications with regard to their contents, functions and usability, so as to overcome the obstacles to their use and ensure greater evidence of the benefits of their use.