Browsing by Author "Oliveira, S."
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- Differential imune response to vitamin A in B16-F10 malignant melanocytesPublication . Oliveira, S.; Coelho, Pedro; Costa, J.; Prudêncio, Cristina; Soares, R.; Guerreiro, S. G.; Fernandes, RúbenMelanoma is an aggressive form of skin cancer with a poor prognosis, due to its refractory behavior to radiation and chemotherapy. Although the diagnosis is straightforward, there are many disagreements regarding its treatment and surveillance. In order to surpass some of the limitations addressed to the treatment, preventive methods like antioxidant vitamins are nowadays a relevant field of research, as well as immunostimulation by external agents. Despite the knowledge about melanoma biology, pathogenesis and developed therapies, is important to understand the effect of vitamin A in order to suggest alternatives to conventional therapies, which are known to be ineffective against melanoma.
- Metabolic syndrome and inflammation: is there a microvascular and an incretin system impairment in the gastrointestinal tract?Publication . Costa, J.; Almeida, J.; Coelho, Pedro; Oliveira, S.; Prudêncio, Cristina; Soares, R.; Gomes-Guerreiro, S.; Fernandes, RúbenMetabolic syndrome is a multifactorial disorder characterized by increased plasma levels of glucose, cholesterol and triglycerides, but also overweight and obesity promoted by increase of body fat mass, alterations in oxidative stress, chronic low grade inflammation and resistance to insulin leading to risk of cardiovascular diseases. The stomach and the intestine have an essential role in metabolism with functions of digesting food and absorption of nutrients. Also, the intestine produces incretin hormones, such as GLP-1 which regulates glucose metabolism and processes of the gastrointestinal tract.
- The role of MTHFR polymorphisms in breast cancer risk– A metaanalysisPublication . Costa, J.; Oliveira, S.; Oliveira, R.; Prudêncio, Cristina; Fernandes, RúbenBreast cancer incidence has been increasing by more than one million new cases every year and is a primary cause of cancer death among women worldwide. Methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and as a regulator of DNA methylation, synthesis, and repair. MTHFR gene is polymorphic at nucleotides 677 (C®T) and 1298 (A®C), resulting in allozymes with decreased activity. Several studies have pointed to association between the MTHFR C677T polymorphism and breast cancer risk.