Percorrer por autor "Oliveira, Catarina"
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- Literacia em saúde mental na perturbação de hiperatividade e défice de atenção: estudo pilotoPublication . Gonçalves, Ana Rita; Oliveira, Catarina; Trigueiro, Maria João; Simões-Silva, VítorDiversos estudos referem Portugal como o segundo país com a prevalência de doenças psiquiátricas mais elevada da Europa (22,9%), sendo importante aumentar a literacia da população. O nosso objetivo foi avaliar a eficácia da formação sobre PHDA, realizada através da plataforma Bicho 7 Cabeças, no aumento do conhecimento de indivíduos adultos, sem formação na área da saúde. A amostra é constituída por 16 indivíduos, entre os 18 e os 29 anos, sendo cinco do sexo masculino. Destes, 50% têm o 12º ano, 31,25% são licenciados e 18,75% têm mestrado. Foram usados como medidas de conhecimento o valor obtido nos resultados após a formação e numa questão sobre do nivel de conhecimento do indivíduo sobre PHDA, juntamente com o questionário de usabilidade. Os resultados demonstraram um aumento do conhecimento sobre PHDA, independentemente do sexo, idade e escolaridade. A média do conhecimento obtida na formação é de 8,36 em 10 e em todas as avaliações, a percentagem foi superior a 70%. A usabilidade da plataforma foi avaliada positivamente pelos indivíduos. Através do presente estudo foi possível verificar a eficácia da plataforma Bicho 7 Cabeças, no aumento da literacia da população.
- Nanotechnology and antioxidant therapy: An emerging approach for neurodegenerative diseasesPublication . Fernandes, Carlos; Oliveira, Catarina; Benfeito, Sofia; Soares, Pedro; Garrido, Jorge; Borges, FernandaThe efficacy, cellular uptake and specific transport of dietary antioxidants to target organs, tissues and cells remains the most important setback for their application in the treatment of oxidative-stress related disorders and in particular in neurodegenerative diseases, as brain targeting remains a still unsolved challenge. Nanotechnology based delivery systems can be a solution for the above mentioned problems, specifically in the case of targeting dietary antioxidants with neuroprotective activity. Nanotechnology-based delivery systems can protect antioxidants from degradation, improve their physicochemical drug-like properties and in turn their bioavailability. The impact of nanomedicine in the improvement of the performance of dietary antioxidants, as protective agents in oxidative- stress events, specifically through the use of drug delivery systems, is highlighted in this review as well as the type of nanomaterials regularly used for drug delivery purposes. From the data one can conclude that the research combining (dietary) antioxidants and nanotechnology, namely as a therapeutic solution for neurodegenerative diseases, is still in a very early stage. So, a huge research area remains to be explored that hopefully will yield new and effective neuroprotective therapeutic agents in a foreseeable future.
- Rehabilitation outcomes and parameters of blood flow restriction training in ACL injury: a scoping reviewPublication . Caetano, Daniel; Oliveira, Catarina; Correia, Cristiana; Barbosa, Pedro; Mesquita Montes, António; Carvalho, PauloTo identify the outcomes of physical function, physical fitness, training, and cuff parameters, used in BFRT in ACL rehabilitation. This scoping review was initiated on April 25th, 2020, according to the PRISMA Extension for Scoping Reviews (PRISMA-ScR). Relevant literature was identified searching three main concepts: BFRT, rehabilitation and ACL injury on MEDLINE (PubMed), CENTRAL of Cochrane Library, Web of Science and PEDro. Studies looking at adults with a primary ACL injury undergoing conservative or pre/post-surgery rehabilitation with BFR or BFRT, with physical fitness and physical function as outcomes or other physical outcomes were included. Sixty-eight articles were identified and six were included. One article was added through backward tracking. All studies used BFRT in the ACL injury surgical rehabilitation. Most studies evaluated physical fitness (muscular strength and volume) however, physical function was not considered a pri mary outcome. Training and cuff parameters were heterogeneously prescribed. The existing evidence is not enough to draw definitive conclusions due to the heterogenous reported outcomes and parameters. Future investigation with standardized outcome measures and specific protocols are needed to draw conclusions on patients’ physical function, so BFRT can be used more effectively in clinical rehabilitation practice.
- Sequence alignment: Comparative analysis of algorithms in KRAS genetic mutationsPublication . Pereira, Ana Rita; Lopes, Carlos; Oliveira, Catarina; Pereira, Gonçalo; Moreira, Rui; Faria, Brígida Mónica; Faria, Brigida MonicaFor this study a program was developed in Python on biological sequence alignment, considering the application of algorithms in the genetic analysis of Kristen rat sarcoma viral oncogene (KRAS) and its main mutations associated with cancer. The KRAS gene, like other genes in the same family, is responsible for encoding proteins that regulate cell proliferation, differentiation, and apoptosis. The algorithms employed include the Needleman-Wunsch algorithm as well as the Smith-Waterman algorithm and the Basic Local Alignment Search Tool (BLAST). The algorithms for multiple sequence alignment help to understand the function, evolution, and variability of biological sequences, significantly contributing to advances in genomics and proteomics. The objectives of this study are to apply algorithms for the effective alignment of biological sequences, compare the non-mutated KRAS sequence with principal mutations associated with cancer development, delineate and justify the selection of the algorithms used, assess their computational complexity, and facilitate 3D visualization of the sequences. Development of a program - BioAlign - in Python, with various functions including upload and visualization of sequences; use of different algorithms for global and local alignment; BLAST search; algorithms complexity analysis; obtaining the nucleotides positions; obtaining subsequence and its position; phylogenetic analysis; histogram visualization of sequence length and 3D structure visualization. The program is capable of analyzing and comparing the provided sequences using both local and global algorithms. The execution time among the three main algorithms differs, with the BLAST algorithm notably slower in returning results. This fact may be due to several factors, such as the complexity of the algorithm itself, the internet speed, and the response time of the NCBI website. The development of the BioAlign program indeed allows to address the proposed objectives. Furthermore, the completion of this project has enhanced proficiency in utilizing the Python programming language, demonstrating significant skill development.
- Virtual reality in social skills training programs for people with schizophrenia: A systematic review and focus groupPublication . Oliveira, Catarina; Simões De Almeida, Raquel; Marques, AntónioThis study aims to determine the guidelines for the design of a social skills training programme for people with schizophrenia using virtual reality. This article encompasses two studies: Study 1, a systematic review of five articles indexed in the databases B-on, PubMed, Clinical trials and Cochrane Library (2010–2020); Study 2, a focus group of occupational therapists trained in mental health and multimedia professionals, in which they discussed the outline of such a programme.